Evidence map›Paper›PMID 39221968›Full record

ArticleDevelopment (Cambridge, England)2024

Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation.

Pedro Vallecillo-García, Mira Nicola Kühnlein, Mickael Orgeur, Nils Rouven Hansmeier, Georgios Kotsaris, Zarah Gertrud Meisen, Bernd Timmermann, Claudia Giesecke-Thiel, René Hägerling, Sigmar Stricker

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Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pedro Vallecillo-GarcíaInstitute for Chemistry and Biochemistry, Freie Universität Berlin,14195 Berlin, Germany.ORCID 0000-0001-6833-5972
Mira Nicola KühnleinInstitute for Chemistry and Biochemistry, Freie Universität Berlin,14195 Berlin, Germany.
Mickael OrgeurUnit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, Université Paris Cité, CNRS UMR 6047, 75015 Paris, France.
Nils Rouven HansmeierResearch Group 'Lymphovascular Medicine and Translational 3D-Histopathology' , Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Georgios KotsarisInstitute for Chemistry and Biochemistry, Freie Universität Berlin,14195 Berlin, Germany.
Zarah Gertrud MeisenInstitute for Chemistry and Biochemistry, Freie Universität Berlin,14195 Berlin, Germany.
Bernd TimmermannMax Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Claudia Giesecke-ThielMax Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
René HägerlingResearch Group 'Lymphovascular Medicine and Translational 3D-Histopathology' , Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
Sigmar StrickerInstitute for Chemistry and Biochemistry, Freie Universität Berlin,14195 Berlin, Germany.ORCID 0000-0002-7174-5363

Funding

Berlin Institute of HealthDeutsche Forschungsgemeinschaft VA 1272/1-1European Research Council PREVENTFreie Universität Berlin
6 · The paper itself

Abstract

The lymphatic system is formed during embryonic development by the commitment of specialized lymphatic endothelial cells (LECs) and their subsequent assembly in primary lymphatic vessels. Although lymphatic cells are in continuous contact with mesenchymal cells during development and in adult tissues, the role of mesenchymal cells in lymphatic vasculature development remains poorly characterized. Here, we show that a subpopulation of mesenchymal cells expressing the transcription factor Osr1 are in close association with migrating LECs and established lymphatic vessels in mice. Lineage tracing experiments revealed that Osr1+ cells precede LEC arrival during lymphatic vasculature assembly in the back of the embryo. Using Osr1-deficient embryos and functional in vitro assays, we show that Osr1 acts in a non-cell-autonomous manner controlling proliferation and early migration of LECs to peripheral tissues. Thereby, mesenchymal Osr1+ cells control, in a bimodal manner, the production of extracellular matrix scaffold components and signal ligands crucial for lymphatic vessel formation.

Indexed as

Endothelial CellsLymphangiogenesisLymphatic VesselsTranscription FactorsAnimalsCell LineageCell MovementCell ProliferationEmbryo, MammalianGene Expression Regulation, DevelopmentalMesenchymal Stem CellsMesodermMiceOsr1 protein, mouseTranscription FactorsCxcl12Extracellular matrixLymphatic vasculatureMesenchymal cellOsr1

Identifiers

PMID39221968
PMCPMC11441984

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