Evidence map›Paper›PMID 39221574›Full record

ArticleMuscle & nerve2024

Skeletal muscle symptoms and quantitative MRI in females with dystrophinopathy.

Breana M Jenkins, Lathan D Dixon, Kevin J Kokesh, Carla D Zingariello, Krista Vandenborne, Glenn A Walter, Alison M Barnard

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01484678 (Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01484678 recruitingnot on this map

Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

TypeobservationalSponsorUniversity of FloridaRan2020 to 2026Enrolled550ConditionsDuchenne Muscular Dystrophy, Becker Muscular Dystrophy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Balanced Translocations Involving theInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Breana M JenkinsDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Lathan D DixonDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Kevin J KokeshDivision of Pulmonology, Department of Pediatrics at the time of the study, University of Florida, Gainesville, Florida, USA.
Carla D ZingarielloDivision of Pediatric Neurology, Department of Pediatrics, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0001-9884-2190
Krista VandenborneDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Glenn A WalterDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, USA.
Alison M BarnardDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.ORCID https://orcid.org/0000-0001-7715-0865

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
NCATS NIH HHS UL1 TR001427NICHD NIH HHS K12 HD055929NIH HHSParent Project Muscular DystrophyUniversity of Florida
6 · The paper itself

Abstract

INTRODUCTION/

aimsThe dystrophinopathies primarily affect males; however, female carriers of pathogenic dystrophin variants can develop skeletal muscle symptoms. This study aimed to evaluate muscle involvement and symptoms in females with dystrophinopathy using quantitative magnetic resonance imaging (MRI), functional assessments, and patient-reported outcomes.

methodsControls and females with dystrophinopathy with muscle symptoms of pain, weakness, fatigue, or excessive tightness were enrolled in this cross-sectional study. Participants underwent lower extremity MRI to quantify muscle inflammation, replacement by fat, and disease asymmetry. Cardiac MRI, functional ability, muscle symptoms, and serum creatine kinase levels were also evaluated.

resultsSix pediatric females with dystrophinopathy (mean age: 11.7 years), 11 adult females with dystrophinopathy (mean age: 41.3 years), and seven controls enrolled. The mean fat fraction was increased in females with dystrophinopathy compared to controls in the soleus (0.11 vs. 0.03, p = .0272) and vastus lateralis (0.16 vs. 0.03, p = .004). Magnetic resonance spectroscopy water T DISCUSSION: Symptomatic females with dystrophinopathy quantitatively demonstrate muscle replacement by fat and inflammation, along with impairments in functional ability and cardiac function. Additional research is needed to evaluate how symptoms and muscle involvement change longitudinally.

Indexed as

Magnetic Resonance ImagingMuscle, SkeletalAdolescentAdultChildCreatine KinaseCross-Sectional StudiesDystrophinFemaleHumansMiddle AgedYoung AdultCreatine KinaseDystrophinDuchenne muscular dystrophyfat fractioninflammationmagnetic resonance imagingx‐inactivation

Identifiers

PMID39221574
PMCPMC11493146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.