Evidence map›Paper›PMID 39221544›Full record

ArticleJournal of the International Association of Providers of AIDS Care

Patient Participant Perspectives on Implementation of Long-Acting Cabotegravir and Rilpivirine: Results From the Cabotegravir and Rilpivirine Implementation Study in European Locations (CARISEL) Study.

Cassidy A Gutner, Marc van der Valk, Joaquin Portilla, Eliette Jeanmaire, Leïla Belkhir, Thomas Lutz, Rebecca DeMoor, Rekha Trehan, Jenny Scherzer, Miguel Pascual-Bernáldez and 10 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Development of a Layperson Injector Training for the Home-Based Administration of Long-Acting Injectable Antiretroviral Therapies for Persons With HIV.AIDS education and prevention : official publication of the International Society for AIDS Education · 2026
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Cassidy A GutnerViiV Healthcare, Durham, NC, USA.
Marc van der ValkDepartment of Infectious Diseases, Amsterdam University Medical Centers, University of Amsterdam and Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands.
Joaquin PortillaHospital General Universitario Dr Balmis de Alicante, Alicante, Spain.
Eliette JeanmaireService de Maladies Infectieuses et Tropicales, Hôpital Brabois, CHRU de Nancy, Vandoeuvre-lès-Nancy, France.
Leïla BelkhirCliniques Universitaires Saint-Luc, Brussels, Belgium.
Thomas LutzInfektiologikum, Frankfurt am Main, Germany.
Rebecca DeMoorGSK, Collegeville, PA, USA.
Rekha TrehanViiV Healthcare, London, UK.
Jenny ScherzerViiV Healthcare, Munich, Germany.
Miguel Pascual-BernáldezViiV Healthcare, Madrid, Spain.
Mounir Ait-KhaledViiV Healthcare, London, UK.
Beatriz HernandezViiV Healthcare, Madrid, Spain.
Annemiek de RuiterViiV Healthcare, London, UK.
Savita Bakhshi AnandEvidera, London, UK.
Emma L LowEvidera, London, UK.
Monica HadiEvidera, London, UK.
Nicola BarnesEvidera, London, UK.
Nick SevdalisCentre for Behavioural and Implementation Science Interventions, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore.
Perry MohammedViiV Healthcare, London, UK.
Maggie CzarnogorskiViiV Healthcare, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCARISEL is an implementation-effectiveness "hybrid" study examining the perspectives of people living with HIV-1 (patient study participants [PSPs]) on cabotegravir (CAB) plus rilpivirine (RPV) long-acting (LA) dosed every 2 months (Q2M) across 5 European countries.

methodsPSPs completed questionnaires on acceptability (Acceptability of Intervention Measure), appropriateness (Intervention Appropriateness Measure), and feasibility (Feasibility of Intervention Measure) at their first (Month [M] 1), third (M4), and seventh (M12) injection visits. Semistructured qualitative interviews were also conducted.

resultsOverall, 437 PSPs were enrolled, of whom 430 received treatment. Median (interquartile range) age was 44 (37-51) years, 25.3% (n = 109/430) were female (sex at birth), and 21.9% (n = 94/430) were persons of color. Across time points, PSPs found CAB + RPV LA highly acceptable, appropriate, and feasible (mean scores ≥4.47/5). Qualitative data supported these observations.

conclusionsPSPs found CAB + RPV LA Q2M to be an acceptable, appropriate, and feasible treatment option.

Indexed as

Anti-HIV AgentsHIV InfectionsPyridonesRilpivirineAdultDiketopiperazinesEuropeFemaleHIV-1HumansMaleMiddle AgedSurveys and QuestionnairesAnti-HIV AgentscabotegravirDiketopiperazinesPyridonesRilpivirineacceptabilityappropriatenesscabotegravir + rilpivirinelong-actingsatisfactionstigma

Identifiers

PMID39221544
PMCPMC11367594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.