Evidence map›Paper›PMID 39221506›Full record

ArticleAdvanced healthcare materials2024

An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein.

Yixuan Li, Liuxiong Luo, Lenart Senicar, Rica Asrosa, Burcu Kizilates, Kaizhong Xing, Elias Torres, Lizhou Xu, Danyang Li, Neil Graham and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yixuan LiInstitute for Materials Discovery, Department of Chemistry, University College London, London, WC1E 7JE, UK.ORCID 0009-0003-0589-2124
Liuxiong LuoSchool of Materials Science and Engineering, Central South University, Changsha, 410083, P. R. China.
Lenart SenicarInstitute for Materials Discovery, Department of Chemistry, University College London, London, WC1E 7JE, UK.
Rica AsrosaInstitute for Materials Discovery, Department of Chemistry, University College London, London, WC1E 7JE, UK.
Burcu KizilatesInstitute for Materials Discovery, Department of Chemistry, University College London, London, WC1E 7JE, UK.
Kaizhong XingYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.
Elias TorresGraphenea Semiconductor, Paseo Mikeletegi 83, San Sebastián, 20009, Spain.
Lizhou XuCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
Danyang LiResearch Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, P. R. China.
Neil GrahamDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
Amanda HeslegraveUK Dementia Research Institute at UCL, University College London, London, WC1E 6BT, UK.
Henrik ZetterbergUK Dementia Research Institute at UCL, University College London, London, WC1E 6BT, UK.
David J SharpDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
Bing LiInstitute for Materials Discovery, Department of Chemistry, University College London, London, WC1E 7JE, UK.ORCID 0000-0002-1737-3423

Funding

Alzheimer's Association ADSF-21-831376-CAlzheimer's Association ADSF-21-831377-CAlzheimer's Association ADSF-21-831381-CAlzheimer's Association ADSF-24-1284328-CAlzheimer's Drug Discovery Foundation 201809-2016862China Scholarship Council 202006370079Cure Alzheimer's FundEngineering and Physical Sciences Research Council EP/X525649/1EU Joint Programme - Neurodegenerative Disease Research JPND2021-00694European Union's Horizon Europe research and innovation programme 101053962Familjen Erling-Perssons StiftelseH2020 Marie Skłodowska-Curie Actions 860197Medical Research Council EP/X525649/1Medical Research Council MR/X502984/1National Institute for Health and Care Research NIHR-RP-011-048Olav Thon StiftelsenRosetrees Trust Seedcorn2023∖100182Royal Society IEC∖NSFC∖223128Royal Society RG∖R1∖241087Stiftelsen för Gamla Tjänarinnor FO2022-0270Swedish Research Council #2019-02397Swedish Research Council #2022-01018Swedish Research Council #2023-00356Swedish State Support for Clinical Research #ALFGBG-71320UCLH Biomedical Research CentreUK Dementia Research Institute UKDRI-1003University College London
6 · The paper itself

Abstract

Accurate assessment of neurological disease through monitoring of biomarkers has been made possible using the antibody-based assays. But these assays suffer from expensive development of antibody probes, reliance on complicated equipments, and high maintenance costs. Here, using the novel reduced graphene oxide/polydopamine-molecularly imprinted polymer (rGO/PDA-MIP) as the probe layer, a robust electrochemical sensing platform is demonstrated for the ultrasensitive detection of glial fibrillary acidic protein (GFAP), a biomarker for a range of neurological diseases. A miniaturized integrated circuit readout system is developed to interface with the electrochemical sensor, which empowers it with the potential to be used as a point-of-care (POC) diagnostic tool in primary clinical settings. This innovative platform demonstrated good sensitivity, selectivity, and stability, with imprinting factor evaluated as 2.8. A record low limit-of-detection (LoD) is down to 754.5 ag mL

Indexed as

Electrochemical TechniquesGlial Fibrillary Acidic ProteinGraphiteLimit of DetectionMolecular ImprintingPoint-of-Care SystemsPolymersBiomarkersBiosensing TechniquesHumansIndolesMolecularly Imprinted PolymersBiomarkersGlial Fibrillary Acidic Proteingraphene oxideGraphiteIndolesMolecularly Imprinted PolymerspolydopaminePolymersglial fibrillary acidic proteinmolecularly imprinted polymerneurological disease monitoringpoint‐of‐care electrochemical sensorreduced graphene oxide

Identifiers

PMID39221506
PMCPMC11616259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.