Evidence map›Paper›PMID 39221464›Full record

ArticleJournal of child neurology2024

Lyme Disease and Papilledema: A Retrospective Study on Clinical Characteristics and Outcomes.

Joseph Vithayathil, Akash Virupakshaiah, Geraldine Liu, Sanjeev K Swami, Robert A Avery, Grant T Liu, Jennifer L McGuire

Abstract read
In one paragraph

Article in Journal of child neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph VithayathilDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-1070-5237
Akash VirupakshaiahDepartment of Neurology, Division of Neuroimmunology and Glial Biology, University of California, San Francisco, Los Angeles, USA.ORCID 0000-0003-2624-9974
Geraldine LiuDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sanjeev K SwamiDivision of Infectious Disease, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert A AveryDivision of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Grant T LiuDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Jennifer L McGuireDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

PENN Vision Clinical Scientist ProgramK12EY015398 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2004 to 2026
$11.7M
Altered Brain Structure and Function in Adolescents with Behaviorally Acquired HIVK23NS094069 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MCGUIRE, JENNIFER L · 2016 to 2020
$904k
NEI NIH HHS K12 EY015398NINDS NIH HHS K23 NS094069
6 · The paper itself

Abstract

objectiveDescribe the clinical characteristics, treatment strategies, and outcome data of children with papilledema associated with Lyme disease at a large tertiary care pediatric hospital.

methodsRetrospective cohort study of children 1-18 years old who received care at our institution between 1995 and 2019 with concurrent diagnoses of papilledema and Lyme disease. Data were abstracted from records and prospective family surveys.

resultsAmong 44 children included (median age 9.7 years), 66% (29/44) had additional cranial neuropathies, and 78% (32/41) had cerebrospinal fluid pleocytosis. All children were treated with antibiotics (39% oral, 55% intravenous, 7% both); 61% (27/44) were also treated with oral acetazolamide. Symptoms fully resolved in 86% (30/35) of children with follow-up data. Proportion recovered did not significantly differ by antibiotic administration route or presence/absence of cerebrospinal fluid pleocytosis.

conclusionsPapilledema in Lyme disease may occur with or without cerebrospinal fluid pleocytosis. Most children recover without residual deficits following treatment, although exceptions exist.

Indexed as

Anti-Bacterial AgentsLyme DiseasePapilledemaAcetazolamideAdolescentChildChild, PreschoolFemaleHumansInfantLeukocytosisMaleRetrospective StudiesTreatment OutcomeAcetazolamideAnti-Bacterial Agentsintracranial hypertensionneuroophthalmologypediatric

Identifiers

PMID39221464
PMCPMC11464175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.