Evidence map›Paper›PMID 39221275›Full record

ArticlePeerJ2024

Fecal shedding of SARS-CoV-2 in infants born to SARS-CoV-2 positive mothers: a pilot study.

Dylan K P Blaufus, Karen M Kalanetra, Rosa Pesavento, Pranav Garlapati, Brittany C Baikie, Kara M Kuhn-Riordon, Mark A Underwood, Diana H Taft

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dylan K P BlaufusDepartment of Food Science and Technology, University of California, Davis, CA, United States of America.
Karen M KalanetraDepartment of Food Science and Technology, University of California, Davis, CA, United States of America.
Rosa PesaventoDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States of America.
Pranav GarlapatiDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States of America.
Brittany C BaikieDepartment of Food Science and Technology, University of California, Davis, CA, United States of America.
Kara M Kuhn-RiordonDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States of America.
Mark A UnderwoodDepartment of Pediatrics, University of California, Davis, Sacramento, CA, United States of America.
Diana H TaftDepartment of Food Science and Human Nutrition, University of Florida, Gainesville, FL, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fecal shedding of SARS-CoV-2 occurs during infection, particularly in pediatric populations. The gut microbiota are associated with resistance to enteric pathogens. COVID-19 is associated with alterations to the gut microbiome. We hypothesized that the gut microbiome of infants born to SARS-CoV-2+ mothers differs between infants with and without fecal shedding of the virus. Methods: We enrolled 10 infants born to SARS-CoV-2+ mothers. We used qPCR on fecal RNA to test for SARS-CoV-2 and 16S rRNA gene sequencing of the V4 region to assess the gut microbiome. Infant SARS-CoV-2 status from nasal swabs was abstracted from medical records. Results: Of the 10 included infants, nine were tested for SARS-CoV-2 by nasal swab with 1 testing positive. Four infants, including the nasal swab positive infant, had at least one sample with detectable levels of SARS-CoV-2 fecal shedding. Detection of both SARS-CoV-2 genes in feces was associated with increased gut alpha diversity compared to no detection by a linear mixed effects model ( Conclusion: Fecal shedding of SARS-CoV-2 occurs in infants who test negative on nasal swabs and is associated with differences in the gut microbiome.

Indexed as

COVID-19FecesGastrointestinal MicrobiomeSARS-CoV-2Virus SheddingAdultFemaleHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaleMothersPilot ProjectsPregnancyPregnancy Complications, InfectiousRNA, Ribosomal, 16SFecal sheddingInfant gut microbiomeSARS-CoV-2

Identifiers

PMID39221275
PMCPMC11363909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.