Evidence map›Paper›PMID 39221265›Full record

ArticlePeerJ2024

Levels of biomarkers associated with subconcussive head hits in mixed martial arts fighters.

Nelson Marinho de Lima Filho, Sabrina Gabrielle Gomes Fernandes, Valeria Costa, Daline Araujo, Clecio Godeiro, Gerlane Guerra, Ricardo Oliveira Guerra, Karyna Figueiredo Ribeiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nelson Marinho de Lima FilhoDepartment of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil.
Sabrina Gabrielle Gomes FernandesDepartment of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil.
Valeria CostaHealth Science Center, Postgraduate Program in Drug Development and Technological Innovation, Federal University of Rio Grande do Norte, Natal, Brazil.
Daline AraujoHealth Sciences College of Trairi, Federal University of Rio Grande do Norte, Santa Cruz, Brazil.
Clecio GodeiroDepartment of Integrated Medicine, Federal University of Rio Grande do Norte, Natal, Brazil.
Gerlane GuerraDepartment of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil.
Ricardo Oliveira GuerraDepartment of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil.
Karyna Figueiredo RibeiroDepartment of Physiotherapy, Federal University of Rio Grande do Norte, Natal, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES)
6 · The paper itself

Abstract

Background: Concussion and the damage resulting from this event related to brain function have been widely studied; however, little is known about subconcussive impacts, especially in Mixed Martial Arts (MMA) fighters, which is a combat and full contact sport in which most blows are aimed at the head. Objective: This study aims to evaluate the biomarker levels associated with subconcussive hits to the head in MMA fighters. Methods: This is an exploratory study in which 30 male subjects (10 MMA fighters, 10 healthy individuals who practice muscle training, and 10 healthy sedentary individuals) aged between 18 and 32 years (25.4 ± 3.8) were evaluated. These individuals underwent blood collection to assess their Ubiquitin C-terminal hydrolase (UCH-L1), Glial Fibrillary Acidic Protein (GFAP) and Brain Derived Neurotrophic Factor (BDNF) levels before, immediately after and 72 hours after the sparring session (for the fighters) and were compared between groups. Results: Significant differences were found at baseline between active and healthy fighters in BDNF levels ( Conclusion: Despite the exploratory approach, the findings of this study may help to understand the influence of repeated subconcussive hits to the head in MMA fighters, as well as to propose preventive interventions which can minimize the effects of the impact of hits, preserving fighters' neuronal integrity and function.

Indexed as

BiomarkersBrain ConcussionBrain-Derived Neurotrophic FactorMartial ArtsAdolescentAdultGlial Fibrillary Acidic ProteinHumansMaleUbiquitin ThiolesteraseYoung AdultBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorGFAP protein, humanGlial Fibrillary Acidic ProteinUbiquitin ThiolesteraseUCHL1 protein, humanBiomarkersConcussionSport contactTrauma

Identifiers

PMID39221265
PMCPMC11365479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.