Evidence map›Paper›PMID 39221223›Full record

ArticleJCEM case reports2024

Euglycemic Ketoacidosis From Semaglutide in a Patient Without Diabetes.

Nikhil Sood, Ojas Bansal, Rohini Garg, Abhinav Hoskote

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nikhil SoodDepartment of Hospital Medicine, Banner Health, Gilbert, AZ 85234, USA.ORCID https://orcid.org/0009-0007-9456-5828
Ojas BansalDepartment of Cardiology, Banner Health, Mesa, AZ 85202, USA.
Rohini GargDepartment of Internal Medicine, CHI Health Mercy Hospital, Council Bluffs, IA 51503, USA.
Abhinav HoskoteDepartment of Internal Medicine, WellSpan York Hospital, York, PA 17403, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Euglycemic ketoacidosis is a medical emergency characterized by euglycemia, metabolic acidosis, and ketonemia. It is a well-recognized adverse event in patients with diabetes taking sodium-glucose cotransporter-2 inhibitors. However, little has been reported about euglycemic ketoacidosis using glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide. We present a case of euglycemic ketoacidosis in a young female without diabetes who was taking semaglutide for weight loss for the last 7 months. She was treated with bicarbonate-containing dextrose infusion, which improved the ketoacidosis rapidly. The incidence of euglycemic ketoacidosis will likely increase with the increasing use of GLP-1 inhibitors, and recognizing the signs and symptoms of this life-threatening condition is essential to treat it effectively. Our literature search identified 1 reported case of euglycemic ketoacidosis in a patient without diabetes associated with tirzepatide but none with semaglutide.

Indexed as

euglycemic ketoacidosisGLP-1 agonistpatients without diabetessemaglutideWegovy

Identifiers

PMID39221223
PMCPMC11362620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.