Evidence map›Paper›PMID 39221222›Full record

ArticleMaterials today. Bio2024

A self-fused peptide-loaded hydrogel with injectability and tissue-adhesiveness for preventing postoperative peritoneal adhesions.

Zequn Zhang, Chao Yin, Xianwen Song, Xi Liu, Chonglei Zhong, Jun Zheng, Yaqiong Ni, Rujuan Shen, Yihang Guo, Xiaorong Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zequn ZhangDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Chao YinHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Xianwen SongHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Xi LiuDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Chonglei ZhongDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Jun ZhengHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Yaqiong NiHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Rujuan ShenState Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, China.
Yihang GuoDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Xiaorong LiDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Changwei LinDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Yi ZhangHunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.
Gui HuDepartment of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal adhesions commonly occur following abdominal or pelvic surgery and can cause serious complications. Currently, physical barriers are the primary approach used in clinical practice to prevent adhesion, although their effectiveness is frequently inadequate. In this study, we developed an injectable peptide-loaded hydrogel with multiple functions, including self-fusion, tissue-adhesiveness, anti-inflammation, anti-cell adhesion and anti-angiogenesis. To assess the effectiveness of these hydrogels, which are stabilized by dynamic imine bonds and acetal connections, in preventing postoperative abdominal adhesions, we utilized both a rat abdominal adhesion model and a rat model simulating repeated-injury adhesions. In comparison to the commercially available HA hydrogel, as-prepared hydrogels exhibited significant reductions in inflammation, fibrosis, and angiogenesis, leading to an obvious decrease in peritoneal adhesions. Moreover, this peptide-loaded hydrogel demonstrated an ideal degradation time, maintaining an in vivo viability for about 10 days. We believe this peptide-loaded hydrogel presents a promising solution for the challenging clinical issue of postoperative abdominal adhesions.

Indexed as

Dynamic crosslinkingEndostatinHydrogelPostoperative adhesionRecurrent adhesions

Identifiers

PMID39221222
PMCPMC11364900

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.