Evidence map›Paper›PMID 39221179›Full record

ReviewVaccine: X2024

COVID-19 vaccines are effective at preventing symptomatic and severe infection among healthcare workers: A clinical review.

Oliver Galgut, Fiona Ashford, Alexandra Deeks, Andeep Ghataure, Mimia Islam, Tanvir Sambhi, Yiu Wayn Ker, Christopher J A Duncan, Thushan I de Silva, Susan Hopkins and 4 more

Abstract readReview
In one paragraph

Review in Vaccine: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Oliver GalgutInstitute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, UK.
Fiona AshfordInstitute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, UK.
Alexandra DeeksNIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Andeep GhataureCollege of Medical and Dental Science, University of Birmingham, Birmingham, UK.
Mimia IslamCollege of Medical and Dental Science, University of Birmingham, Birmingham, UK.
Tanvir SambhiCollege of Medical and Dental Science, University of Birmingham, Birmingham, UK.
Yiu Wayn KerCollege of Medical and Dental Science, University of Birmingham, Birmingham, UK.
Christopher J A DuncanTranslational and Clinical Research Institute Immunity and Inflammation Theme, Newcastle University, Newcastle, UK.
Thushan I de SilvaDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Susan HopkinsUnited Kingdom Health Security Agency, Colindale, London, UK.
Victoria HallUnited Kingdom Health Security Agency, Colindale, London, UK.
Paul KlenermanNIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Susanna DunachieNIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Alex RichterInstitute of Immunology and Immunotherapy, College of Medical and Dental Science, University of Birmingham, Birmingham, UK.

Funding

Medical Research Council MR/X001598/1Medical Research Council MR/X009297/1
6 · The paper itself

Abstract

Introduction: Health care workers (HCWs) have been at increased risk of infection during the SARS-CoV-2 pandemic and as essential workers have been prioritised for vaccination. Due to increased exposure HCW are considered a predictor of what might happen in the general population, particularly working age adults. This study aims to summarise effect of vaccination in this 'at risk' cohort. Methods: Ovid MEDLINE and Embase were searched, and 358 individual articles were identified. Of these 49 met the inclusion criteria for review and 14 were included in a meta-analysis. Results: Participants included were predominantly female and working age. Median time to infection was 51 days. Reported vaccine effectiveness against infection, symptomatic infection, and infection requiring hospitalisation were between 5 and 100 %, 34 and 100 %, and 65 and 100 % (respectively). No vaccinated HCW deaths were recorded in any study. Pooled estimates of protection against infection, symptomatic infection, and hospitalisation were, respectively, 84.7 % (95 % CI 72.6-91.5 %, Conclusions: Vaccination against SARS-CoV2 in HCWs is protective against infection, symptomatic infection, and hospitalisation. Waning protection is reported but this awaits more mature studies to understand durability more clearly. This study is limited by varying non-pharmacological responses to COVID-19 between included studies, a predominantly female and working age population, and limited information on asymptomatic transmission or long COVID protection.

Indexed as

Adenovirus vectorCOVID-19Healthcare workermRNASARS-CoV-2Vaccine

Identifiers

PMID39221179
PMCPMC11364133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.