Evidence map›Paper›PMID 39221150›Full record

ArticleFrontiers in pharmacology2024

Topiramate inhibits adjuvant-induced chronic orofacial inflammatory allodynia in the rat.

Violetta Mohos, Máté Harmat, Jozsef Kun, Tímea Aczél, Balázs Zoltán Zsidó, Tamás Kitka, Sándor Farkas, Erika Pintér, Zsuzsanna Helyes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Violetta MohosDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Máté HarmatDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Jozsef KunDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Tímea AczélDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Balázs Zoltán ZsidóDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Tamás KitkaUzsoki Cardiovascular Center Ltd., Budapest, Hungary.
Sándor FarkasUzsoki Cardiovascular Center Ltd., Budapest, Hungary.
Erika PintérDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Zsuzsanna HelyesDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic orofacial pain disorders are common debilitating conditions, affecting the trigeminal system. Its underlying pathophysiological mechanisms are still unclear and the therapy is often unsatisfactory, therefore, preclinical models are crucial to identify the key mediators and novel treatment options. Complete Freund's adjuvant (CFA)-induced orofacial inflammatory allodynia/hyperalgesia is commonly used in rodents, but it has not been validated with currently used drugs. Here we tested the effects of the adjuvant analgesic/antiepileptic voltage-gated Na

Indexed as

animal modelcomplete Freund’s adjuvantinflammatory painmechanical allodyniaorofacial painsumatriptantopiramatetrigeminal activation

Identifiers

PMID39221150
PMCPMC11361966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.