ArticleEnvironmental science and ecotechnology2024
Unravelling biosynthesis and biodegradation potentials of microbial dark matters in hypersaline lakes.
Article in Environmental science and ecotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Uncovering syntrophic potential from genome-resolved metagenomics of suspended and granular anaerobic digestion sludges.FEMS microbiology ecology · 2026Article
- Microbial decomposer diversity and metabolic function during the decomposition of brine shrimp carcasses in a saline lake.Microbiome · 2026Article
- Integrated omics analyses reveal insights into microbial dark matter associated with deep-sea water in Central Indian Ocean.World journal of microbiology & biotechnology · 2026Article
- Contrasting salinity regimes reshape microbe-DOM coupling and reduce recalcitrant dissolved organic carbon preservation in a salt lake.The ISME journal · 2026Article
- Metagenomics-assembled genomes reveal microbial metabolic adaptation to athalassohaline environment, the case Lake Barkol, China.Frontiers in microbiology · 2025Article
- Microbial dark matter spearheading the biogeochemical cycle in the Solar Lake of Taba, Egypt.Current research in microbial sciences · 2025Article
- Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
11 authors.
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Abstract
Biosynthesis and biodegradation of microorganisms critically underpin the development of biotechnology, new drugs and therapies, and environmental remediation. However, most uncultured microbial species along with their metabolic capacities in extreme environments, remain obscured. Here we unravel the metabolic potential of microbial dark matters (MDMs) in four deep-inland hypersaline lakes in Xinjiang, China. Utilizing metagenomic binning, we uncovered a rich diversity of 3030 metagenome-assembled genomes (MAGs) across 82 phyla, revealing a substantial portion, 2363 MAGs, as previously unclassified at the genus level. These unknown MAGs displayed unique distribution patterns across different lakes, indicating a strong correlation with varied physicochemical conditions. Our analysis revealed an extensive array of 9635 biosynthesis gene clusters (BGCs), with a remarkable 9403 being novel, suggesting untapped biotechnological potential. Notably, some MAGs from potentially new phyla exhibited a high density of these BGCs. Beyond biosynthesis, our study also identified novel biodegradation pathways, including dehalogenation, anaerobic ammonium oxidation (Anammox), and degradation of polycyclic aromatic hydrocarbons (PAHs) and plastics, in previously unknown microbial clades. These findings significantly enrich our understanding of biosynthesis and biodegradation processes and open new avenues for biotechnological innovation, emphasizing the untapped potential of microbial diversity in hypersaline environments.
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