Evidence map›Paper›PMID 39220854›Full record

ArticleDEN open2025

Lumen-apposing metal stents provide early and late clinical benefits for the management of benign gastrointestinal strictures: Is there a role for definitive therapy?

Ethan Pollack, Dalton Norwood, Hector Caceres, Babusai Rapaka, Isaac E Perry, Usman Barlass, Rachel Mitchell, Jessica McCreight, Shajan Peter, Ramzi Mulki and 3 more

Abstract read
In one paragraph

Article in DEN open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ethan PollackDepartment of Internal Medicine The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.ORCID https://orcid.org/0000-0002-7607-9507
Dalton NorwoodDepartment of Internal Medicine UAB Minority Health and Health Equity Research Center The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Hector CaceresDepartment of Internal Medicine UAB Minority Health and Health Equity Research Center The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Babusai RapakaDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Isaac E PerryDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Usman BarlassDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Rachel MitchellDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Jessica McCreightDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Shajan PeterDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Ramzi MulkiDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Ali AhmedDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Kondal KyanamDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.
Sergio A Sánchez-LunaDepartment of Internal Medicine Division of Gastroenterology & Hepatology Basil I. Hirschowitz Endoscopic Center of Excellence The University of Alabama at Birmingham Heersink School of Medicine Birmingham Alabama USA.ORCID https://orcid.org/0000-0001-6870-2226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to characterize the clinical outcomes, safety, and efficacy of lumen-apposing metal stents (LAMS) in treating benign gastrointestinal strictures. Methods: A single-center retrospective review of all patients who underwent LAMS placement for benign strictures from June 2017 to July 2023. Primary outcomes were technical success, early clinical success, late clinical success (LCS), and sustained post-LAMS clinical success (SPLCS). Secondary outcomes included stent dwell time, stenosis changes, adverse events, reintervention rates, and symptomatology evaluation. Results: Thirty-five patients underwent placement of 42 LAMS (74% female, mean age: 54.2 ± 11.7 years). Anastomotic strictures accounted for 64% of cases ( Conclusions: LAMS for benign gastrointestinal strictures are associated with high technical and early clinical success/LCS rates, positive quality-of-life metrics, and a tolerable adverse event rate. Overall, recurrence of symptoms and high reintervention rates post-LAMS removal reinforce the difficulty in managing benign gastrointestinal strictures but also argue for LAMS as a definitive therapy in select cases.

Indexed as

gastrointestinal disordersgastrointestinal endoscopesgastrointestinal tractstentsstrictures

Identifiers

PMID39220854
PMCPMC11366066

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.