Evidence map›Paper›PMID 39220688›Full record

ArticleACS central science2024

Melissa Thaler, Tim P Ofman, Ken Kok, Jurriaan J A Heming, Elisha Moran, Isabelle Pickles, Anouk A Leijs, Adrianus M C H van den Nieuwendijk, Richard J B H N van den Berg, Gijs Ruijgrok and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Melissa ThalerLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Tim P OfmanLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Ken KokLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Jurriaan J A HemingLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Elisha MoranDepartment of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID https://orcid.org/0000-0002-3463-6862
Isabelle PicklesDepartment of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID https://orcid.org/0000-0002-8495-5570
Anouk A LeijsLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Adrianus M C H van den NieuwendijkLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Richard J B H N van den BergLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Gijs RuijgrokLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Zachary ArmstrongLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.ORCID https://orcid.org/0000-0002-4086-2946
Clarisse Salgado-BenvindoLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Dennis K NinaberDepartment of Pulmonology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Eric J SnijderLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Constant A A van BoeckelLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.
Marta ArtolaLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.ORCID https://orcid.org/0000-0002-3051-3902
Gideon J DaviesDepartment of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID https://orcid.org/0000-0002-7343-776X
Herman S OverkleeftLeiden Institute of Chemistry, Leiden University, 2311 EZ Leiden, The Netherlands.ORCID https://orcid.org/0000-0001-6976-7005
Martijn J van HemertLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID https://orcid.org/0000-0002-2617-9243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combined inhibition of endoplasmic reticulum (ER) α-glucosidases I and II has been shown to inhibit replication of a broad range of viruses that rely on ER protein quality control. We found, by screening a panel of deoxynojirimycin and cyclitol glycomimetics, that the mechanism-based ER α-glucosidase II inhibitor, 1,6-

Identifiers

PMID39220688
PMCPMC11363342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.