Evidence map›Paper›PMID 39220673›Full record

ArticleStat (International Statistical Institute)2024

Deep learning models to predict primary open-angle glaucoma.

Ruiwen Zhou, J Philip Miller, Mae Gordon, Michael Kass, Mingquan Lin, Yifan Peng, Fuhai Li, Jiarui Feng, Lei Liu

Abstract read
In one paragraph

Article in Stat (International Statistical Institute), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruiwen ZhouDivision of Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
J Philip MillerDivision of Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.
Mae GordonDepartment of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Michael KassDepartment of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Mingquan LinDepartment of Population Health Sciences, Weill Cornell Medicine, New York City, New York, USA.ORCID 0000-0003-0862-6588
Yifan PengDepartment of Population Health Sciences, Weill Cornell Medicine, New York City, New York, USA.
Fuhai LiInstitute for Informatics (I2), Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Jiarui FengDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
Lei LiuDivision of Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1844-338X

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Achieving Model Fairness on Automatic Primary Open-angle Glaucoma ScreeningR21EY035296 · NEI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PENG, YIFAN · 2023 to 2023
$466k
Innovative Analytical Methods for DNA Methylation AgeR21AG068955 · NIA · WASHINGTON UNIVERSITY · PI LIU, LEI, ZHENG, YINAN · 2021 to 2022
$448k
Innovative Analytical Methods for Repeated Measures in the OHTS StudyR21EY031884 · NEI · WASHINGTON UNIVERSITY · PI GORDON, MAE O, LIU, LEI · 2020 to 2021
$439k
Resubmission: Latent Class Trajectory Analysis in the OHTS StudyR21EY033518 · NEI · WASHINGTON UNIVERSITY · PI GORDON, MAE O, LIU, LEI · 2022 to 2023
$430k
NCATS NIH HHS UL1 TR002345NEI NIH HHS R21 EY031884NEI NIH HHS R21 EY033518NEI NIH HHS R21 EY035296NIA NIH HHS R21 AG068955
6 · The paper itself

Abstract

Glaucoma is a major cause of blindness and vision impairment worldwide, and visual field (VF) tests are essential for monitoring the conversion of glaucoma. While previous studies have primarily focused on using VF data at a single time point for glaucoma prediction, there has been limited exploration of longitudinal trajectories. Additionally, many deep learning techniques treat the time-to-glaucoma prediction as a binary classification problem (glaucoma Yes/No), resulting in the misclassification of some censored subjects into the nonglaucoma category and decreased power. To tackle these challenges, we propose and implement several deep-learning approaches that naturally incorporate temporal and spatial information from longitudinal VF data to predict time-to-glaucoma. When evaluated on the Ocular Hypertension Treatment Study (OHTS) dataset, our proposed convolutional neural network (CNN)-long short-term memory (LSTM) emerged as the top-performing model among all those examined. The implementation code can be found online (https://github.com/rivenzhou/VF_prediction).

Indexed as

convolutional neural networkdynamic predictionlandmark analysislong short-term memory

Identifiers

PMID39220673
PMCPMC11364364

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.