Evidence map›Paper›PMID 39220530›Full record

ArticleACS omega2024

Synthetic Naphthoquinone Inhibits Herpes Simplex Virus Type-1 Replication Targeting Na

Kauê Francisco Corrêa de Souza E Souza, Vitor Won-Held Rabelo, Paula Alvarez Abreu, Cláudio César Cirne Santos, Nayane Abreu do Amaral E Silva, Daniela de Luna, Vitor Francisco Ferreira, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Cassiano Felippe Gonçalves-de-Albuquerque and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kauê Francisco Corrêa de Souza E SouzaDepartamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-201, Brazil.ORCID https://orcid.org/0000-0001-9767-8560
Vitor Won-Held RabeloDepartamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-201, Brazil.
Paula Alvarez AbreuInstituto de Biodiversidade e Sustentabilidade, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro CEP 27965-045, Brazil.
Cláudio César Cirne SantosDepartamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-201, Brazil.
Nayane Abreu do Amaral E SilvaDepartamento de Química, Instituto de Química, Laboratório de Catálise e Síntese (Lab CSI), Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-141, Brazil.
Daniela de LunaDepartamento de Química, Instituto de Química, Laboratório de Catálise e Síntese (Lab CSI), Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-141, Brazil.ORCID https://orcid.org/0000-0001-6657-040X
Vitor Francisco FerreiraDepartamento de Tecnologia Farmacêutica, Universidade Federal Fluminense, Faculdade de Farmácia, Niterói, Rio de Janeiro 24241-002, Brazil.
Bernardo Ferreira BrazDepartamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro CEP 21941-909, Brazil.
Ricardo Erthal SantelliDepartamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro CEP 21941-909, Brazil.
Cassiano Felippe Gonçalves-de-AlbuquerqueLaboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Rio de Janeiro CEP 21040-900 Brazil.
Izabel Christina Nunes de Palmer PaixãoDepartamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-201, Brazil.
Patricia BurthDepartamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro CEP 24020-201, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 1970 acyclovir (ACV) has been the reference drug in treating herpes simplex virus (HSV) infections. However, resistant herpes simplex virus type 1 (HSV-1) strains have emerged, narrowing the treatment efficacy. The antiviral activity of classical Na

Identifiers

PMID39220530
PMCPMC11360054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.