Evidence map›Paper›PMID 39220490›Full record

ArticleACS omega2024

Characterization of the SARS-CoV-2 Genome 3'-Untranslated Region Interactions with Host MicroRNAs.

Caleb J Frye, Caylee L Cunningham, Mihaela Rita Mihailescu

Abstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Caleb J FryeDepartment of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.
Caylee L CunninghamDepartment of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.
Mihaela Rita MihailescuDepartment of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282, United States.ORCID https://orcid.org/0000-0002-1162-7699

Funding

Investigation of Fragile X mental retardation protein interactions with the miRNA pathway.R15GM127307 · NIGMS · DUQUESNE UNIVERSITY · PI MIHAILESCU, MIHAELA R · 2017 to 2023
$928k
NIGMS NIH HHS R15 GM127307
6 · The paper itself

Abstract

The 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has marked the spread of a novel human coronavirus. SARS-CoV-2 has exhibited increased disease severity and immune evasion across its variants, and the molecular mechanisms behind these phenomena remain largely unknown. Conserved elements of the viral genome, such as secondary structures within the 3'-untranslated region (UTR), could prove crucial in furthering our understanding of the host-virus interface. Analysis of the SARS-CoV-2 viral genome 3'-UTR revealed the potential for host microRNA (miR) binding sites, allowing for sequence-specific interactions. In this study, we demonstrate that the SARS-CoV-2 genome 3'-UTR binds the host cellular miRs miR-34a-5p, miR-34b-5p, and miR-760-3p

Identifiers

PMID39220490
PMCPMC11360049

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.