Evidence map›Paper›PMID 39220414›Full record

ArticleBrain & spine2024

Incidence, surgical eligibility and outcome of spontaneous intracerebral haemorrhage in Southwest Finland - A retrospective study.

Sami Lehto, Antti Sajanti, Santtu Hellström, Fredrika Koskimäki, Abhinav Srinath, Carolyn Bennett, Julián Carrión-Penagos, Ying Cao, Miro Jänkälä, Romuald Girard and 3 more

Abstract read
In one paragraph

Article in Brain & spine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sami LehtoNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Antti SajantiNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Santtu HellströmNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Fredrika KoskimäkiNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Abhinav SrinathNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Carolyn BennettNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Julián Carrión-PenagosDepartment of Neurology, University of Chicago Medicine and The University of Chicago, IL, USA.
Ying CaoDepartment of Radiation Oncology, Kansas University Medical Center, Kansas City, KS, USA.
Miro JänkäläDepartment of Neurosurgery, Oulu University Hospital and University of Oulu, Finland.
Romuald GirardNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Jaakko RinneNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Melissa RahiNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.
Janne KoskimäkiNeurocenter, Department of Neurosurgery, Turku University Hospital and University of Turku, Finland.

Funding

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0M
NICHD NIH HHS T32 HD007009
6 · The paper itself

Abstract

Introduction: Spontaneous intracerebral haemorrhage (sICH) is a major cause of morbidity and mortality. Large-scale trials have shown neutral outcomes for surgical interventions. The recent trial suggested functional benefits from surgical intervention. Surgical treatment for sICH is likely increasing. Research question: To determine the incidence of sICH in Southwest Finland, standardized to the European population, and to identify the proportion of large sICH patients eligible for surgery based on previously published trial criteria. We also examined factors associated with outcomes, including the effects of anticoagulant and antithrombotic medications. Material and methods: A retrospective clinical study identified 596 ICH cases treated at Turku University Hospital (2018-2019), of which 286 were supratentorial sICHs. Variables were analysed using a Results: The sICH incidence was 29.9/100,000 persons per year, with the highest European population age and sex standardized rates in individuals over 80 years old (110/100,000 males, 142/100,000 females). The incidence of sICH patients meeting surgical criteria was 2.7/100,000 persons per year. Out of 286 patients, 26 were eligible for surgery and had unfavourable outcomes (p = 0.0049). Multivariate analysis indicated a significant decrease in favourable outcomes with warfarin (p = 0.016, OR 0.42) and direct-acting anticoagulants (DOACs) (p = 0.034, OR 0.38), while antithrombotic medications showed no significant effect. Discussion and conclusion: We identified comparable incidence of sICH as European average. A small proportion of sICH cases were identified to be candidates for surgical intervention. Anticoagulants were associated with increased risk of unfavourable outcomes.

Indexed as

AnticoagulantsICHIncidenceIntracerebral haemorrhageOutcomeSurgery

Identifiers

PMID39220414
PMCPMC11365294

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.