Evidence map›Paper›PMID 39220256›Full record

ArticleiScience2024

A physico-mechanical model of postnatal craniofacial growth in human.

Ce Liang, Arsalan Marghoub, Antonio Profico, Costantino Buzi, Marius Didziokas, Lara van de Lande, Roman Hossein Khonsari, David Johnson, Paul O'Higgins, Mehran Moazen

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ce LiangDepartment of Mechanical Engineering, University College London, London WC1E 7JE, UK.
Arsalan MarghoubDepartment of Mechanical Engineering, University College London, London WC1E 7JE, UK.
Antonio ProficoDepartment of Biology, University of Pisa, 56126 Pisa, Italy.
Costantino BuziInstitut Català de Paleoecologia Humana i Evolució Social (IPHES-CERCA), 43007 Tarragona, Spain.
Marius DidziokasDepartment of Mechanical Engineering, University College London, London WC1E 7JE, UK.
Lara van de LandeDepartment of Oral and Maxillofacial Surgery, Erasmus Medical Centre, 3015 GD Rotterdam, the Netherlands.
Roman Hossein KhonsariCraniofacial Growth and Form Laboratory, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Faculté de Médecine, Université Paris Cité, 75015 Paris, France.
David JohnsonOxford Craniofacial Unit, Oxford University Hospital, Oxford OX3 9DU, UK.
Paul O'HigginsDepartment of Archaeology and Hull York Medical School, University of York, York YO10 5DD, UK.
Mehran MoazenDepartment of Mechanical Engineering, University College London, London WC1E 7JE, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our fundamental understanding of the physico-mechanical forces that drive the size and shape changes of the cranium during ontogeny are limited. Biomechanical models based on finite element method present a huge opportunity to address this critical gap in our knowledge. Here, we describe a validated computational framework to predict normal craniofacial growth. Our results demonstrated that this approach is capable of predicting the growth of calvaria, face, and skull base. We highlighted the crucial role of skull base in antero-posterior growth of the face and also demonstrated the contribution of the maxillary expansion to the dorsoventral growth of the face and its interplay with the orbits. These findings highlight the importance of physical interactions of different components of the craniofacial system. The computational framework described here serves as a powerful tool to study fundamental questions in developmental biology and to advance treatment of conditions affecting the craniofacial system such as craniosynostosis.

Indexed as

Biological constraintsDevelopmental biologyIn silico biology

Identifiers

PMID39220256
PMCPMC11365398

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.