Evidence map›Paper›PMID 39220243›Full record

ArticleNeuro-oncology advances

Racial distribution of molecularly classified brain tumors.

Camila S Fang, Wanyi Wang, Chanel Schroff, Misha Movahed-Ezazi, Varshini Vasudevaraja, Jonathan Serrano, Erik P Sulman, John G Golfinos, Daniel Orringer, Kristyn Galbraith and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Camila S FangDepartment of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-8477-1253
Wanyi WangDepartment of Biostatistics, NYU School of Global Public Health, New York, New York, USA.
Chanel SchroffDepartment of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.
Misha Movahed-EzaziDepartment of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-9249-5498
Varshini VasudevarajaDepartment of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0001-9678-6375
Jonathan SerranoDepartment of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-2839-9573
Erik P SulmanBrain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0003-4933-9120
John G GolfinosBrain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0003-4221-0180
Daniel OrringerDepartment of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0001-6427-8376
Kristyn GalbraithDepartment of Pathology NYU Langone Health and NYU Grossman School of Medicine, New York, New York, USA.ORCID https://orcid.org/0000-0002-5660-866X
Yang FengDepartment of Biostatistics, NYU School of Global Public Health, New York, New York, USA.
Matija SnuderlBrain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York, USA.ORCID https://orcid.org/0000-0003-0752-0917

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Clinical Translation of Stimulated Raman HistologyR01CA226527 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ORRINGER, DANIEL · 2018 to 2025
$4.4M
Inducing Neural Maturation in Medulloblastoma by Targeting EZH2R01NS122987 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAJU, PRAVEEN B., SNUDERL, MATIJA · 2022 to 2025
$2.8M
Inducing neural maturation in medulloblastoma by targeting EZH2R56NS122987 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAJU, PRAVEEN B., SNUDERL, MATIJA · 2021 to 2021
$461k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA226527NINDS NIH HHS R01 NS122987NINDS NIH HHS R56 NS122987
6 · The paper itself

Abstract

Background: In many cancers, specific subtypes are more prevalent in specific racial backgrounds. However, little is known about the racial distribution of specific molecular types of brain tumors. Public data repositories lack data on many brain tumor subtypes as well as diagnostic annotation using the current World Health Organization classification. A better understanding of the prevalence of brain tumors in different racial backgrounds may provide insight into tumor predisposition and development, and improve prevention. Methods: We retrospectively analyzed the racial distribution of 1709 primary brain tumors classified by their methylation profiles using clinically validated whole genome DNA methylation. Self-reported race was obtained from medical records. Our cohort included 82% White, 10% Black, and 8% Asian patients with 74% of patients reporting their race. Results: There was a significant difference in the racial distribution of specific types of brain tumors. Blacks were overrepresented in pituitary adenomas (35%, Conclusions: Molecularly classified brain tumor groups and subgroups show different distributions among the three main racial backgrounds suggesting the contribution of race to brain tumor development.

Indexed as

CNS tumor prevalenceDNA methylationethnicityrace

Identifiers

PMID39220243
PMCPMC11362849

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.