Evidence map›Paper›PMID 39220156›Full record

ArticleFrontiers in pediatrics2024

Case Report: Aplastic anemia related to a novel

Geoffrey Hall, Janet G Markle, James Maiarana, Paul L Martin, Jennifer A Rothman, John W Sleasman, Howard Lederman, Antoine E Azar, Robert A Brodsky, Talal Mousallem

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Geoffrey HallDepartment of Pediatrics, Division of Allergy and Immunology, Duke University, Durham, NC, United States.
Janet G MarkleDepartment of Pathology, Microbiology and Immunology, and Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United States.
James MaiaranaDepartment of Pathology, Microbiology and Immunology, and Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United States.
Paul L MartinDepartment of Pediatrics, Division of Transplant and Cellular Therapy, Duke University, Durham, NC, United States.
Jennifer A RothmanDepartment of Pediatrics, Division of Pediatric Hematology/Oncology, Duke University, Durham, NC, United States.
John W SleasmanDepartment of Pediatrics, Division of Allergy and Immunology, Duke University, Durham, NC, United States.
Howard LedermanDepartment of Pediatrics, Division of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins, Baltimore, MD, United States.
Antoine E AzarDepartment of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins, Baltimore, MD, United States.
Robert A BrodskyDepartment of Medicine, Division of Hematology, Johns Hopkins, Baltimore, MD, United States.
Talal MousallemDepartment of Pediatrics, Division of Allergy and Immunology, Duke University, Durham, NC, United States.

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)P30HD106451 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI Lang Li, Sara K Quinney · 2021 to 2026
$24.1M
RESEARCH TRAINING IN ALLERGY AND CLINICAL IMMUNOLOGYT32AI007062 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David B. Peden, John W. Sleasman · 1985 to 2026
$6.1M
From genetic variants to mechanisms: understanding drivers of inflammationR35GM155339 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Janet G Markle · 2024 to 2026
$1.3M
NIAID NIH HHS T32 AI007062NICHD NIH HHS P30 HD106451NIDDK NIH HHS P30 DK058404NIGMS NIH HHS R35 GM155339
6 · The paper itself

Abstract

A 20-year-old male patient with a history of celiac disease came to medical attention after developing profound fatigue and pancytopenia. Evaluation demonstrated pan-hypogammaglobulinemia. There was no history of significant clinical infections. Bone marrow biopsy confirmed hypocellular marrow consistent with aplastic anemia. Oncologic and hematologic evaluations were unremarkable for iron deficiency, paroxysmal nocturnal hemoglobinuria, myelodysplastic syndromes, T-cell clonality, and leukemia. A next generation genetic sequencing immunodeficiency panel revealed a heterozygous variant of uncertain significance in

Indexed as

Aplastic anemiaCTLA-4haploinsufficiencyhematopoietic stem cell transplantation (HSCT)inborn error of immunity (IEI)novel variant

Identifiers

PMID39220156
PMCPMC11363706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.