Evidence map›Paper›PMID 39220111›Full record

ArticleMolecular therapy. Oncology2024

Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification.

Jason M Tonne, Karol Budzik, Talia Fernandez Carrasco, Landon Ebbert, Jill Thompson, Rebecca Nace, Benjamin Kendall, Rosa M Diaz, Stephen J Russell, Richard G Vile

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jason M TonneDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Karol BudzikDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Talia Fernandez CarrascoDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Landon EbbertDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Jill ThompsonDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Rebecca NaceDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Benjamin KendallDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Rosa M DiazDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Stephen J RussellDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Richard G VileDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Funding

Characterizing the role of CSDE1 as a critical co-factor for VSV replication.R01AI170535 · NIAID · MAYO CLINIC ROCHESTER · PI Richard G. Vile · 2023 to 2026
$1.6M
Re-purposing Oncolytic Virotherapy to Re-invigorate CAR T Cell Therapy for Solid Tumors.R01CA269384 · NCI · MAYO CLINIC ROCHESTER · PI Richard G. Vile · 2023 to 2026
$1.4M
Research Training Program in Neuro-OncologyT32CA217836 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK, VILE, RICHARD G. · 2018 to 2022
$1.4M
NCI NIH HHS R01 CA269384NCI NIH HHS T32 CA217836NIAID NIH HHS R01 AI170535
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T cells have had limited success against solid tumors. Here, we used an oncolytic foamy virus (oFV) to display a model CAR target antigen (CD19) on tumors in combination with anti-CD19 CAR T cells. We generated oFV-Δ

Indexed as

ApobeccancerCAR T-cellCD19MT: Regular Issueoncolytic virotherapySimian foamy virusviral mutationviral vectors

Identifiers

PMID39220111
PMCPMC11362648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.