ArticleCureus2024
VACTERL Association in a Fetus With a Normal Genetic Profile.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular mechanism, diagnosis, and treatment of VACTERL association.Frontiers in pediatrics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
VACTERL association is a statistical association of vertebral(V), anal(A), cardiac(C), tracheoesophageal(TE), renal(R), and limb(L) abnormalities (VACTERL). Diagnosis of VACTERL can be made if anomalies in three or more organ systems indicated by the acronym are present and no other recognizable pattern of human malformations exists. We hereby present a case of a primigravida in her 20s, whose prenatal scan at 13 weeks of gestation revealed a fetus having a short spine, single outflow tract, and increased nuchal translucency. Chromosome microarray on amniotic fluid showed no quantitative genomic imbalance. A repeat scan at 21 weeks disclosed lumbar scoliosis with hemivertebrae, tetralogy of Fallot, and a single umbilical artery. After undergoing counselling, in light of the adverse outcomes and poor quality of life of the offspring, the parents decided to terminate the pregnancy. The abortus was subsequently sent to the histopathology lab for autopsy. The gross examination of the fetus unveiled an umbilical cord with only two vessels, right congenital talipes equinovarus (club foot), left congenital talipes equinovalgus, and right foot polydactyly. Internal examination of the cardiovascular system verified the presence of tetralogy of Fallot. The kidogram of the fetus was consistent with a butterfly vertebral body of D11 and D12 with right-side hemivertebrae. This case illustrates the importance of foetal autopsy for confirming the prenatal diagnosis and identifying abnormalities in syndromes or associations. The classification especially plays a crucial role in the case of recurrent abortions to point out the underlying aetiology and counsel the parents regarding the recurrence risk.
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Registered trials
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