Evidence map›Paper›PMID 39219841›Full record

ArticleGene reports2024

Genetic contributions to pain modulation in sickle cell: A focus on single nucleotide polymorphisms.

Katrina R Hamilton, Lakeya S McGill, Claudia M Campbell, Sophie M Lanzkron, C Patrick Carroll, Alban Latremoliere, Jennifer A Haythornthwaite, Olga A Korczeniewska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrina R HamiltonDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Lakeya S McGillDepartment of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Claudia M CampbellDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Sophie M LanzkronDepartment of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
C Patrick CarrollDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Alban LatremoliereDepartment of Neurosurgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Jennifer A HaythornthwaiteDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Olga A KorczeniewskaCenter for Orofacial Pain and Temporomandibular Disorders, Department of Diagnostic Sciences, Rutgers School of Dental Medicine, Newark, NJ, USA.

Funding

University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)K12NS130673 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Daniel J Clauw, Steven Edward Harte · 2022 to 2026
$12.5M
Research Training in Rehabilitation for Brain Injury and Neurological DisabilityT32HD007414 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Amy J. Bastian · 1991 to 2026
$6.3M
Interdisciplinary Training in Biobehavioral Pain ResearchT32NS070201 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DONG, XINZHONG, SMITH, MICHAEL T · 2010 to 2024
$3.6M
Sleep and Pain in Sickle Cell DiseaseR01HL133327 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CAMPBELL, CLAUDIA MICHELLE, HAYTHORNTHWAITE, JENNIFER A · 2016 to 2019
$3.1M
Clinical Implications of Pain Phenotypes in Sickle Cell DiseaseR01HL098110 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HAYTHORNTHWAITE, JENNIFER A · 2009 to 2013
$1.8M
Mentorship of Junior Investigators on HEAL-SKOAPK24AR081143 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAMPBELL, CLAUDIA MICHELLE · 2021 to 2021
$324k
NHLBI NIH HHS R01 HL098110NHLBI NIH HHS R01 HL133327NIAMS NIH HHS K24 AR081143NIA NIH HHS L30 AG084087NICHD NIH HHS T32 HD007414NINDS NIH HHS K12 NS130673NINDS NIH HHS T32 NS070201
6 · The paper itself

Abstract

Background: Despite recent advances in our knowledge of genetic contributions to the highly variable sickle cell disease (SCD) phenotype, our understanding of genetic factors associated with pain sensitivity in SCD remains limited. Previous studies investigated specific variants in single candidate genes and their association with SCD pain variability. The primary aim of the current study was to expand the genes and polymorphisms tested to discover new risk genes (polymorphisms) associated with central sensitization for individuals with SCD. Methods: Adults with sickle cell disease ( Results: Central sensitization and general pain sensitivity were not associated with hemoglobin genotype (Ps > 0.05). Of 4145 SNPs tested, following false discovery rate adjustments, 11 SNPs (rs11575839, rs12185625, rs12289836, rs1493383, rs2233976, rs3131787, rs3739693, rs4292454, rs4364, rs4678, rs6773307) were significantly associated with central sensitization, and one SNP (rs7778077) was significantly associated with average weekly non-crisis pain. No SNPs were associated with general pain sensitivity. Conclusions: These findings provide insights into genetic variants association with average non-crisis pain and central sensitization for individuals with SCD, and may provide support for genetic predictors of heightened pain experience within SCD.

Indexed as

Central sensitizationHemoglobin genotypePainQuantitative sensory testingSickle cellSingle nucleotide polymorphism

Identifiers

PMID39219841
PMCPMC11361162

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.