Evidence map›Paper›PMID 39219714›Full record

ArticleCurrent opinion in biomedical engineering2024

Achieving tendon enthesis regeneration across length scales.

Ismael Bousso, Guy Genin, Stavros Thomopoulos

Abstract read
In one paragraph

Article in Current opinion in biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ismael BoussoDepartment of Biomedical Engineering, Columbia University, New York, NY USA.
Guy GeninDepartment of Mechanical Engineering & Materials Science, Washington University, St. Louis, MO USA.
Stavros ThomopoulosDepartment of Biomedical Engineering, Columbia University, New York, NY USA.

Funding

Strain Analysis Software for Open ScienceR01AR077793 · NIAMS · WASHINGTON UNIVERSITY · PI Guy M Genin, Stavros Thomopoulos · 2020 to 2026
$5.2M
Formation of a functional tendon enthesis during development and healingR01AR080717 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Thomopoulos · 2023 to 2026
$1.9M
Biomimetic approaches for enthesis tissue engineeringR01AR080924 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Thomopoulos, YOUNAN XIA · 2023 to 2026
$1.9M
NIAMS NIH HHS R01 AR077793NIAMS NIH HHS R01 AR080717NIAMS NIH HHS R01 AR080924
6 · The paper itself

Abstract

Surgical reattachment of tendon to bone is a clinical challenge, with unacceptably high retear rates in the early period after repair. A primary reason for these repeated tears is that the multiscale toughening mechanisms found at the healthy tendon enthesis are not regenerated during tendon-to-bone healing. The need for technologies to improve these outcomes is pressing, and the tissue engineering community has responded with many advances that hold promise for eventually regenerating the multiscale tissue interface that transfers loads between the two dissimilar materials, tendon, and bone. This review provides an assessment of the state of these approaches, with the aim of identifying a critical agenda for future progress.

Indexed as

biomechanicsenthesismultiscalerotator cufftendontissue engineering

Identifiers

PMID39219714
PMCPMC11364215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.