Evidence map›Paper›PMID 39219688›Full record

ArticleNature. Mental health2024

Symptom dimensions of resting-state electroencephalographic functional connectivity in autism.

Xiaoyu Tong, Hua Xie, Gregory A Fonzo, Kanhao Zhao, Theodore D Satterthwaite, Nancy B Carlisle, Yu Zhang

Abstract read
In one paragraph

Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  18. The Role of Thioredoxin System in Shank3 Mouse Model of Autism.Journal of molecular neuroscience : MN · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xiaoyu TongDepartment of Bioengineering, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0003-2113-5943
Hua XieCenter for Neuroscience Research, Children's National Hospital, Washington, DC, USA.ORCID 0000-0003-3462-0147
Gregory A FonzoCenter for Psychedelic Research and Therapy, Department of Psychiatry and Behavioral Sciences, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-0213-1034
Kanhao ZhaoDepartment of Bioengineering, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0002-2955-0917
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Nancy B CarlisleDepartment of Psychology, Lehigh University, Bethlehem, PA, USA.
Yu ZhangDepartment of Bioengineering, Lehigh University, Bethlehem, PA, USA.ORCID 0000-0003-4087-6544

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Precision mapping of individualized executive networks in youthR37MH125829 · NIMH · UNIVERSITY OF MINNESOTA · PI Damien A Fair, Theodore Satterthwaite · 2021 to 2026
$4.7M
1/2 Neurodevelopmental and clinical trajectories of youth at risk for bipolar I disorderR01MH125886 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI ALMEIDA, JORGE R C, STRAKOWSKI, STEPHEN M · 2021 to 2025
$4.3M
Reproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5M
Establishing Multimodal Brain Biomarkers Using Data-driven Analyticsfor Treatment Selection in DepressionR01MH129694 · NIMH · STANFORD UNIVERSITY · PI Yu Zhang · 2023 to 2026
$2.8M
Characterization of executive function dimensions across pediatric psychiatric disordersR01MH110512 · NIMH · GEORGETOWN UNIVERSITY · PI KENWORTHY, LAUREN, VAIDYA, CHANDAN J · 2016 to 2021
$2.2M
Computational neuroimaging of reward in post-trauma psychopathologyK23MH114023 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI FONZO, GREGORY · 2018 to 2022
$957k
Assess Neural Circuits and Subtypes Underlying Dimensions of Neuropsychiatric Symptoms in Alzheimer's DiseaseR21AG080425 · NIA · LEHIGH UNIVERSITY · PI ZHANG, YU · 2023 to 2024
$426k
Identifying Transdiagnostic Functional Connectivity Biomarkers for Cognitive Health and PsychopathologyR21MH130956 · NIMH · LEHIGH UNIVERSITY · PI BERDICHEVSKY, YEVGENY · 2023 to 2024
$409k
NIA NIH HHS R21 AG080425NIBIB NIH HHS R01 EB022573NIMH NIH HHS K23 MH114023NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH110512NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH120482NIMH NIH HHS R01 MH125886NIMH NIH HHS R01 MH129694NIMH NIH HHS R21 MH130956NIMH NIH HHS R37 MH125829
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by social and communication deficits (SCDs), restricted and repetitive behaviors (RRBs) and fixated interests. Despite its prevalence, development of effective therapy for ASD is hindered by its symptomatic and neurophysiological heterogeneities. To comprehensively explore these heterogeneities, we developed a new analytical framework combining contrastive learning and sparse canonical correlation analysis that identifies symptom-linked resting-state electroencephalographic connectivity dimensions within 392 ASD samples. We present two dimensions with multivariate connectivity basis exhibiting significant correlations with SCD and RRB, confirm their robustness through cross-validation and demonstrate their conceptual generalizability using an independent dataset (

Identifiers

PMID39219688
PMCPMC11361313

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.