Evidence map›Paper›PMID 39219219›Full record

ArticleAdvanced healthcare materials2024

Decellularized Biohybrid Nerve Promotes Motor Axon Projections.

Abijeet Singh Mehta, Sophia L Zhang, Xinran Xie, Shreyaa Khanna, Joshua Tropp, Xudong Ji, Rachel E Daso, Colin K Franz, Sumannas W Jordan, Jonathan Rivnay

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Ultrabright NIR-II Nanoprobes forACS nanoscience Au · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abijeet Singh MehtaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-5759-1716
Sophia L ZhangBiologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.
Xinran XieDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Shreyaa KhannaBiologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.
Joshua TroppDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-1427-1296
Xudong JiDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Rachel E DasoDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-1447-4819
Colin K FranzBiologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.ORCID 0000-0003-4546-8638
Sumannas W JordanBiologics Laboratory, Shirley Ryan Ability Lab, Chicago, IL, 60611, USA.
Jonathan RivnayDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.ORCID 0000-0002-0602-6485

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Belle Carnell Regenerative NeurorehabilitationDivision of Electrical, Communications and Cyber Systems 2023849Materials Research Science and Engineering Center NSF DMR-2308691NCI NIH HHS P30 CA060553Northwestern University Center for Advanced Microscopy CCSG P30 CA060553Office of Naval Research Global N00014-20-1-2777Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource NSF ECCS-2025633
6 · The paper itself

Abstract

Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, biohybrid nerves are developed using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). Nine biohybrid nerves are compared with varying polymerization conditions and cycles, selecting the best candidate through material characterization. These results show that a 1:1 ratio of FeCl

Indexed as

AxonsSciatic NerveAnimalsBridged Bicyclo Compounds, HeterocyclicHumansMotor NeuronsNerve RegenerationPolymersRatsRats, Sprague-DawleySpheroids, CellularSpinal CordTissue EngineeringTissue ScaffoldsBridged Bicyclo Compounds, Heterocyclicpoly(3,4-ethylene dioxythiophene)Polymersbioelectronicsconducting polymersmotor axonspedotspinal spheroids

Identifiers

PMID39219219
PMCPMC11616264

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.