Evidence map›Paper›PMID 39219153›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

The ADNI4 Digital Study: A novel approach to recruitment, screening, and assessment of participants for AD clinical research.

Melanie J Miller, Adam Diaz, Catherine Conti, Bruce Albala, Derek Flenniken, Juliet Fockler, Winnie Kwang, Diana Truran Sacrey, Miriam T Ashford, Caroline Skirrow and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  4. Digital speech-based markers to advance prognosis in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Review
  7. Review
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  10. Article
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  15. Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Contributions of the ADNI Biostatistics Core.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Melanie J MillerNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.ORCID 0000-0002-7189-1109
Adam DiazNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Catherine ContiNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Bruce AlbalaDepartment Environmental & Occupational Health, Public Health, University of California Irvine, Irvine, California, USA.
Derek FlennikenNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Juliet FocklerVA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.
Winnie KwangVA Advanced Imaging Research Center, Department of Veterans Affairs Medical Center, San Francisco, California, USA.
Diana Truran SacreyNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Miriam T AshfordNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Caroline SkirrowNovoic Ltd., London, UK.
Jack WestonNovoic Ltd., London, UK.
Emil FristedNovoic Ltd., London, UK.
Sarah Tomaszewski FariasDepartment of Neurology, University of California, Davis, Davis, California, USA.
Magda KoreckaDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Yang WanDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Paul S AisenAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Laurel BeckettDepartment of Public Health Sciences, University of California, Davis, California, USA.
Danielle HarveyDepartment of Public Health Sciences, University of California, Davis, California, USA.
Edward B LeeDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Leslie M ShawDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Ozioma C OkonkwoWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Monica Rivera MindtDepartments of Psychology, Latin American Latinx Studies Institute, and African and African American Studies, Fordham University, New York, New York, USA.
Michael W WeinerNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Rachel L NoshenyNorthern California Institute for Research and Education (NCIRE), San Francisco, California, USA.
Alzheimer's Disease Neuroimaging Initiative

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
The Brain Health Registry for facilitating interdisciplinary aging researchR33AG062867 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2020 to 2024
$3.2M
NIA NIH HHS P30 AG072972NIA NIH HHS R33 AG062867NIA NIH HHS U19 AG024904NIA NIH HHS U19AG024904
6 · The paper itself

Abstract

introductionWe evaluated preliminary feasibility of a digital, culturally-informed approach to recruit and screen participants for the Alzheimer's Disease Neuroimaging Initiative (ADNI4).

methodsParticipants were recruited using digital advertising and completed digital surveys (e.g., demographics, medical exclusion criteria, 12-item Everyday Cognition Scale [ECog-12]), Novoic Storyteller speech-based cognitive test). Completion rates and assessment performance were compared between underrepresented populations (URPs: individuals from ethnoculturally minoritized or low education backgrounds) and non-URPs.

resultsOf 3099 participants who provided contact information, 654 enrolled in the cohort, and 595 completed at least one assessment. Two hundred forty-seven participants were from URPs. Of those enrolled, 465 met ADNI4 inclusion criteria and 237 evidenced possible cognitive impairment from ECog-12 or Storyteller performance. URPs had lower ECog and Storyteller completion rates. Scores varied by ethnocultural group and educational level. DISCUSSION: Preliminary results demonstrate digital recruitment and screening assessment of an older diverse cohort, including those with possible cognitive impairment, are feasible. Improving engagement and achieving educational diversity are key challenges. HIGHLIGHTS: A total of 654 participants enrolled in a digital cohort to facilitate ADNI4 recruitment. Culturally-informed digital ads aided enrollment of underrepresented populations. From those enrolled, 42% were from underrepresented ethnocultural and educational groups. Digital screening tools indicate > 50% of participants likely cognitively impaired. Completion rates and assessment performance vary by ethnocultural group and education.

Indexed as

Alzheimer DiseasePatient SelectionAgedAged, 80 and overCognitive DysfunctionCohort StudiesFeasibility StudiesFemaleHumansMaleNeuroimagingNeuropsychological TestsSurveys and QuestionnairesAlzheimer's disease (AD)Alzheimer's disease clinical trialsAlzheimer's Disease Neuroimaging Initiative (ADNI)digital assessmentdigital recruitmentparticipant screeningunderrepresented populations

Identifiers

PMID39219153
PMCPMC11485063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.