Evidence map›Paper›PMID 39218959›Full record

ArticleClinical oral investigations2024

Risk factors and impact of occult and skip metastasis in early-stage oral tongue squamous cell carcinoma.

Xiaohuang Yang, Wang Xiang, Yan Sun, Wu Li, Xiaodong Ji, Shanshan Gao, Yu Jiang, Shuang Xia, Jie Shen

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Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiaohuang YangDepartment of Radiology, The First Central Clinical School, Tianjin Medical University, Tianjin, China.
Wang XiangDepartment of Radiology, The First Central Clinical School, Tianjin Medical University, Tianjin, China.
Yan SunDepartment of Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
Wu LiDepartment of Head and Neck Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
Xiaodong JiDepartment of Radiology, The First Central Clinical School, Tianjin Medical University, Tianjin, China.
Shanshan GaoDepartment of Radiology, The First Central Clinical School, Tianjin Medical University, Tianjin, China.
Yu JiangDepartment of Radiology, The First Central Clinical School, Tianjin Medical University, Tianjin, China.
Shuang XiaDepartment of Radiology, Medical Imaging Institute of Tianjin, School of Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, China.
Jie ShenDepartment of Nuclear Medicine, Tianjin First Central Hospital, Tianjin, China. shenjie_vip@126.com.

Funding

the Natural Scientific Foundation of China 82171916the Natural Scientific Foundation of Tianjin 21CYBJC01580the Natural Scientific Foundation of Tianjin 21JCYBJC01060Tianjin Health Science and technology project TJWJ2022XK019Tianjin Health Science and technology project (Specific projects of key disciplines) TJWJ2021MS013Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-041A
6 · The paper itself

Abstract

objectivesTo investigate risk factors associated with occult lymph node metastases (ONM) and skip metastasis in early-stage oral tongue squamous cell carcinoma (OTSCC) patients. Meanwhile, to analyze the contribution of metastatic nodes to survival outcomes. MATERIALS AND

methods544 OTSCC patients who were clinically staged T1-T2N0 with pathologic results from May 2018 to January 2024 were enrolled. Those with ONM were divided into subgroups with or without skip metastasis. Clinical, laboratorial, radiological and pathological factors between groups were analyzed by using univariate analysis and multivariate logistic analysis. The association of tumor growth behavior with the metastatic pattern of lymph nodes was summarized. Additionally, disease free survival (DFS) among different groups were compared using Kaplan-Meier analysis.

resultsTumor growth behavior was associated with ONM. Tumor thickness with a threshold of 6.4 mm was not inferior to histological depth of invasion in predicting ONM. Only 1.3% of patients had nodal involvement of neck level IV or V. The DFS of patients with ONM were significantly reduced than those without ONM (P < 0.001). The DFS between patients with and without skip metastasis exhibited no statistical significance(P = 0.246). The 1-year, 2-year recurrence rates of patients with or without ONM were 31.9%, 37.5%, 10.1% and 14.0%, correspondingly.

conclusionsTumor thickness with a threshold of 6.4 mm could be used as a preoperative predictor for ONM. Elective neck dissection of level I - III might be sufficient for early stage OTSCC patients. OTSCC patients with ONM should be closely observed during the first 2 years after surgery. CLINICAL RELEVANCE: The risk of ONM in early stage OTSCC patients might be predicted by tumor thickness calculated on MR imaging. Elective neck dissection of level I - III could remove micrometastases timely and effectively.

Indexed as

Carcinoma, Squamous CellLymphatic MetastasisNeoplasm StagingTongue NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeck DissectionNeoplasm InvasivenessNeoplasm Recurrence, LocalRetrospective StudiesRisk FactorsDisease free survivalMagnetic resonance imagingOccult lymph node metastasesOral tongue squamous cell carcinomaSkip metastases

Identifiers

PMID39218959

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