Evidence map›Paper›PMID 39218878›Full record

ArticleJournal of nanobiotechnology2024

Ultrasound targeted microbubble destruction assisted exosomal delivery of siHmox1 effectively inhibits doxorubicin-induced cardiomyocyte ferroptosis.

Jianmei Chen, Shuo Qiu, Yang Liu, Wenqi Sun, Tian Zhou, Lianbi Zhao, Zhelong Li, Yunyou Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianmei Chen *Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China.
Shuo Qiu *Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China.
Yang Liu *Department of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China.
Wenqi SunDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China.
Tian ZhouDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China.
Lianbi ZhaoDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China. 328670779@qq.com.
Zhelong LiDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China. lzlfmmu@foxmail.com.
Yunyou DuanDepartment of Ultrasound Diagnostics, Tangdu Hospital, The Fourth Military Medical University, NO. 569th Xinsi Road, Xi'an, Shaanxi, 710038, People's Republic of China. duanyy@fmmu.edu.cn.

Funding

National Natural Science Foundation of China 82202167National Natural Science Foundation of China 82302223
6 · The paper itself

Abstract

Ferroptosis, triggered by iron overload and excessive lipid peroxidation, plays a pivotal role in the progression of DOX-induced cardiomyopathy (DIC), and thus limits the use of doxorubicin (DOX) in clinic. Here, we further showed that cardiac ferroptosis induced by DOX in mice was attributed to up-regulation of Hmox1, as knockdown of Hmox1 effectively inhibited cardiomyocyte ferroptosis. To targeted delivery of siRNA into cardiomyocytes, siRNA-encapsulated exosomes were injected followed by ultrasound microbubble targeted destruction (UTMD) in the heart region. UTMD greatly facilitated exosome delivery into heart. Consistently, UTMD assisted exosomal delivery of siHomox1 nearly blocked the ferroptosis and the subsequent cardiotoxicity induced by doxorubicin. In summary, our findings reveal that the upregulation of HMOX1 induces ferroptosis in cardiomyocytes and UTMD-assisted exosomal delivery of siHmox1 can be used as a potential therapeutic strategy for DIC.

Indexed as

DoxorubicinExosomesFerroptosisHeme Oxygenase-1MicrobubblesMyocytes, CardiacRNA, Small InterferingAnimalsCardiomyopathiesDrug Delivery SystemsMaleMembrane ProteinsMiceMice, Inbred C57BLDoxorubicinHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsRNA, Small InterferingDOX-induced cardiomyopathyExosomesFerroptosissiRNAUltrasound targeted microbubble destruction

Identifiers

PMID39218878
PMCPMC11367924

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.