SynthesisSports medicine (Auckland, N.Z.)2024
Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.
Synthesis in Sports medicine (Auckland, N.Z.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of computer prompt in breaks of sedentary behaviour among office workers: a systematic review and meta-analysis.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Effects of thigh muscle activity patterns on blood pressure and edema during interrupted sitting in overweight and obese men.European journal of applied physiology · 2026Trial
- Optimal 24-h movement behaviors and longitudinal changes in adiposity: a compositional data analysis in school-aged children.European journal of pediatrics · 2026Article
- Implementing an exercise intervention for sarcopenia in oldest-old nursing home residents: protocol for a pragmatic cluster-randomized controlled trial (SCOPE Study).BMC geriatrics · 2026Article
- Association Between Sedentary Behavior Patterns and Glycemic Outcomes in Women with Overweight and Obesity Under Free-Living Conditions.International journal of behavioral medicine · 2026Article
- Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Acute Effects of Interrupting Prolonged Sitting on Glucose, Insulin and Lipid Metabolism in Healthy Populations: A Three-Level Meta-Analysis.Metabolites · 2026Review
- Psychosocial factors associated with physical activity and sedentary behavior in adolescents: evidence from physical education contexts in Quito.Frontiers in psychology · 2026Article
- Article
- Greater amount of lying and reclining associate with cardiovascular disease risk score and several risk factors, while short sitting bouts and standing have opposite relation.American journal of preventive cardiology · 2025Article
- Do COVID-19 recovered individuals differ from healthy controls in accelerometer-measured physical activity and self-reported sleep? a UAE-based study.BMC public health · 2025Article
- Silence of the Muscles: Wearable Electromyography, Sitting, and Type 2 Diabetes.Exercise and sport sciences reviews · 2025Review
- Reliability and validity evidence for the physical activity parenting questionnaire for children (PAP-C) in Chinese school-aged children.European journal of pediatrics · 2025Article
- Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine.Aging clinical and experimental research · 2025Article
- Understanding parental support for children's 24-hour movement behaviors based on an adapted HAPA framework: A three-wave prospective study.Applied psychology. Health and well-being · 2025Article
- Longitudinal relationship between adherence to 24-h Movement Guidelines and adiposity among children.European journal of pediatrics · 2025Article
- Article
- Comprehensive strategies for stroke prevention: A narrative review of population-level risk factor mitigation.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent types of sedentary behavior are associated with several health outcomes, but the causality of these associations remains unclear.
objectivesTo conduct a systematic review and meta-analysis of Mendelian randomization (MR) studies investigating the associations between sedentary behaviors and health outcomes.
methodsA systematic search on PubMed, Embase, Web of Science, Scopus, and PsycINFO up to August 2023 was conducted to identify eligible MR studies. We selected studies that assessed associations of genetically determined sedentary behaviors and health outcomes. A meta-analysis was conducted to examine the causal associations when two or more MR studies were available. We graded the evidence level of each MR association based on the results of the main method and sensitivity analyses in MR studies.
resultsA total of 31 studies with 168 MR associations between six types of sedentary behavior and 47 health outcomes were included. Results from meta-analyses suggested a total of 47 significant causal associations between sedentary behaviors and health outcomes. Notably, more leisure TV watching is robustly correlated with increased risks of myocardial infarction, coronary artery disease, all-cause ischemic stroke, and type 2 diabetes. Conversely, robust inverse associations were observed between leisure computer use and risks of rheumatoid arthritis, Alzheimer's disease, and gastroesophageal reflux disease.
conclusionThese findings suggest that different types of sedentary behavior have distinct causal effects on health outcomes. Therefore, interventions should focus not only on reducing sedentary time but also on promoting healthier types of sedentary behavior. PROSPERO REGISTRATION: CRD42023453828.
Indexed as
Identifiers
39218828What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.