Evidence map›Paper›PMID 39218810›Full record

ArticleCNS neuroscience & therapeutics2024

RNF122 promotes glioblastoma growth via the JAK2/STAT3/c-Myc signaling Axis.

Qingbao Xiao, Kaming Xue, Lin Li, Kai Zhu, Rong Fu, Zhiyong Xiong

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Cancers · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Qingbao XiaoDepartment of Neurosurgery, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Kaming XueDepartment of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lin LiDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Kai ZhuDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Rong FuDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhiyong XiongDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.ORCID 0009-0007-1145-8374

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe E3 ubiquitin ligase is well recognized as a significant contributor to glioblastoma (GBM) progression and has promise as a prospective therapeutic target. This study explores the contribution of E3 ubiquitin ligase RNF122 in the GBM progression and the related molecular mechanisms.

methodsRNF122 expression levels were evaluated using qRT-PCR, WB, and IHC, while functional assays besides animal experiments were used to assess RNF122's effect on GBM progression. We also tested the RNF122 impact on JAK2/STAT3/c-Myc signaling using WB.

resultsRNF122 was upregulated in GBM and correlated to the advanced stage and poor clinical outcomes, representing an independent prognostic factor. Based on functional assays, RNF122 promotes GBM growth and cell cycle, which was validated further in subsequent analyses by JAK2/STAT3/c-Myc pathway activation. Moreover, JAK2/STAT3 signaling pathway inhibitor WP1066 can weaken the effect of overexpression RNF122 on promoting GBM progression.

conclusionOur results revealed that RNF122 caused an aggressive phenotype to GBM and was a poor prognosticator; thus, targeting RNF122 may be effectual in GBM treatment.

Indexed as

Brain NeoplasmsGlioblastomaJanus Kinase 2Proto-Oncogene Proteins c-mycSignal TransductionSTAT3 Transcription FactorUbiquitin-Protein LigasesAnimalsCell Line, TumorCell ProliferationFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceIntracellular Signaling Peptides and ProteinsJAK2 protein, humanJanus Kinase 2Membrane ProteinsMYC protein, humanNMI protein, humanProto-Oncogene Proteins c-mycring finger protein 122, humanSTAT3 protein, humanSTAT3 Transcription FactorUbiquitin-Protein LigasesglioblastomagrowthJAK/STAT/c‐MycRNF122

Identifiers

PMID39218810
PMCPMC11366496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.