Evidence map›Paper›PMID 39217308›Full record

ReviewThe journal of physiological sciences : JPS2024

Role of the central nervous system in cell non-autonomous signaling mechanisms of aging and longevity in mammals.

Takuya Urushihata, Akiko Satoh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of physiological sciences : JPS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Takuya UrushihataDepartment of Integrative Physiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Akiko SatohDepartment of Integrative Physiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. akiko.satoh.b7@tohoku.ac.jp.ORCID http://orcid.org/0009-0004-3668-1087

Funding

Japan Society for the Promotion of Science 22H03548Japan Society for the Promotion of Science 22H04987Japan Society for the Promotion of Science 23H03848Japan Society for the Promotion of Science 23K14671Japan Society for the Promotion of Science 23K18414
6 · The paper itself

Abstract

Multiple organs orchestrate the maintenance of proper physiological function in organisms throughout their lifetimes. Recent studies have uncovered that aging and longevity are regulated by cell non-autonomous signaling mechanisms in several organisms. In the brain, particularly in the hypothalamus, aging and longevity are regulated by such cell non-autonomous signaling mechanisms. Several hypothalamic neurons have been identified as regulators of mammalian longevity, and manipulating them promotes lifespan extension or shortens the lifespan in rodent models. The hypothalamic structure and function are evolutionally highly conserved across species. Thus, elucidation of hypothalamic function during the aging process will shed some light on the mechanisms of aging and longevity and, thereby benefiting to human health.

Indexed as

AgingLongevitySignal TransductionAnimalsCentral Nervous SystemHumansHypothalamusMammalsNeuronsAgingCell non-autonomousCross-species comparisonHypothalamusLongevitySleep

Identifiers

PMID39217308
PMCPMC11365208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.