Evidence map›Paper›PMID 39217247›Full record

Trial reportSpinal cord2024

Effects of exercise on autonomic cardiovascular control in individuals with chronic, motor-complete spinal cord injury: an exploratory randomised clinical trial.

Tristan W Dorey, Tom E Nightingale, Abdullah A Alrashidi, Stefan Thomas, Katharine D Currie, Michèle Hubli, Shane J T Balthazaar, Andrei V Krassioukov

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Spinal cord, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01718977 (Cardiovascular Health/Outcomes), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01718977 nacompletednot on this map

Cardiovascular Health/Outcomes: Improvements Created by Exercise and Education in SCI (CHOICES)

TypeinterventionalSponsorUniversity of British ColumbiaRan2013 to 2019Enrolled46ConditionsSpinal Cord InjuryArmsBody Weight Supported Treadmill Training, Arm Cycle Ergometry Training
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tristan W Dorey *Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Tom E Nightingale *School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0003-2947-4931
Abdullah A AlrashidiInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-1131-756X
Stefan ThomasInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Katharine D CurrieDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Michèle HubliSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.
Shane J T BalthazaarInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Andrei V KrassioukovInternational Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada. krassioukov@icord.org.ORCID 0000-0002-0022-7972

Funding

Canadian HIV Trials Network, Canadian Institutes of Health Research (Réseau canadien pour les essais VIH des IRSC) 412708Canadian HIV Trials Network, Canadian Institutes of Health Research (Réseau canadien pour les essais VIH des IRSC) TCA118348Craig H. Neilsen Foundation 281863Heart and Stroke Foundation of Canada (Heart and Stroke Foundation) 17R26776Michael Smith Foundation for Health Research (MSFHR) 17767
6 · The paper itself

Abstract

STUDY

designSecondary analysis of a clinical trial.

objectiveTo assess the impact of 6 months of arm cycle ergometry training (ACET), or body weight-supported treadmill training (BWSTT), on autonomic cardiovascular responses to a laboratory sit-up test (SUT) in individuals with chronic (≥1-year post-injury) spinal cord injury (SCI).

settingTertiary Rehabilitation Centre, Vancouver, Canada.

methodsSixteen individuals with motor-complete (American Spinal Injury Association Impairment Scale A-B) SCI between the fourth cervical and sixth thoracic spinal cord segments, aged 39 ± 11 years, were assessed. Participants were randomized to receive 72 sessions of moderate-to-vigorous intensity ACET (n = 8) or passive BWSTT (n = 8). Changes in mean arterial pressure (finger plethysmography), hemodynamics (Modelflow® method), and heart rate/heart rate variability (HR/HRV; electrocardiography) were measured in response to a  SUT before and after 6 months of exercise training. Spontaneous cardiovagal baroreflex sensitivity (cvBRS) was assessed using the sequence method.

resultsNeither ACET nor BWSTT impacted hemodynamic responses to SUT or the incidence of orthostatic hypotension (all P > 0.36). ACET increased HR (P < 0.01, η

conclusionSix months of ACET, but not BWSTT, improved cardiovagal baroreflex control of HR but had no effect on BP responses to SUT in individuals with chronic, motor-complete SCI. SPONSORSHIP: Canadian Institutes of Health Research (CIHR) CLINICAL

trial registrationNCT01718977.

Indexed as

Autonomic Nervous SystemExercise TherapyHeart RateSpinal Cord InjuriesAdultBaroreflexBlood PressureChronic DiseaseFemaleHemodynamicsHumansMaleMiddle Aged

Identifiers

PMID39217247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.