Evidence map›Paper›PMID 39217212›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Serum leptin and adiponectin function as indicators of allergic sensitization in pediatric adenotonsillar hypertrophy.

Chaojie Li, Ruixiang Guo, Yanyan Liu, Yijing Zhang, Yan Yang, Shoujie Ni, Xiaojing Sun, Huayang Liu, Zehua Zhao, Yanzhong Li and 3 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Chaojie LiDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Ruixiang GuoDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Yanyan LiuDepartment of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, 250012, China.
Yijing ZhangDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Yan YangDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Shoujie NiDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Xiaojing SunDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Huayang LiuDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Zehua ZhaoDepartment of Hepatology, Qilu Hospital of Shandong University, Jinan, 250012, China.
Yanzhong LiDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Juanjuan ZouDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China. zoujuanjuan_happy@126.com.ORCID http://orcid.org/0000-0002-2228-322X
Yan WangDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China.
Dapeng LeiDepartment of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Shandong University, Jinan, 250012, China. leidapeng@sdu.edu.cn.

Funding

National Natural Science Foundation of China 82000542National Natural Science Foundation of China 82000968
6 · The paper itself

Abstract

purposeObesity is commonly linked to both adenotonsillar hypertrophy (ATH) and allergic disorders, in which the roles of adipokines are not fully illuminated. This study aims to investigate the levels of leptin and adiponectin and their associations with allergic sensitization in pediatric ATH.

methodsSerum levels of specific immunoglobulin E (IgE), leptin and adiponectin were quantified in 35 controls and 111 ATH children, in which 54 were non-atopic and 57 were atopic. Spearman's correlation analysis and polynomial linear trend test were conducted. The odds ratios and 95% confidence intervals were calculated by binary logistic regression after multivariable adjustment.

resultsThe serum level of leptin and leptin/adiponectin (L/A) ratio was significantly increased in children with ATH. An increase in leptin level and L/A ratio and a decrease in adiponectin level were observed in atopic children compared with non-atopic children. Among ATH children, the level of adiponectin was negatively while L/A ratio was positively correlated with specific IgE. After multivariable adjustment, leptin was significantly associated with increased risk of atopy to D. pteronyssinus and D. farina, and adiponectin was significantly associated with decreased risk of atopy to willow and mugwort. Leptin was associated with higher odds while adiponectin was associated with lower odds of overall atopy. Besides, significant multiplicative interactions of obesity with leptin and adiponectin on atopy were observed respectively.

conclusionLeptin and adiponectin were both associated with allergic sensitization and function differently in pediatric ATH. Mechanistic studies are needed to elucidate the involvement of adipokines in allergic sensitization of pediatric ATH.

Indexed as

AdenoidsAdiponectinHypersensitivityLeptinPalatine TonsilBiomarkersCase-Control StudiesChildChild, PreschoolFemaleHumansHypertrophyImmunoglobulin EMaleAdiponectinBiomarkersImmunoglobulin ELeptinAdenotonsillar hypertrophyAdipokineAdiponectinAllergic sensitizationLeptinObesityPediatric

Identifiers

PMID39217212

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.