Evidence map›Paper›PMID 39217140›Full record

ArticleNature communications2024

Competitive processes shape multi-synapse plasticity along dendritic segments.

Thomas E Chater, Maximilian F Eggl, Yukiko Goda, Tatjana Tchumatchenko

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas E Chater *Laboratory for Synaptic Plasticity and Connectivity, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan.
Maximilian F Eggl *Institute of Experimental Epileptology and Cognition Research, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany.ORCID 0000-0001-5815-1045
Yukiko GodaLaboratory for Synaptic Plasticity and Connectivity, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan. yukiko.goda@oist.jp.ORCID 0000-0003-0352-9498
Tatjana TchumatchenkoInstitute of Experimental Epileptology and Cognition Research, University of Bonn Medical Center, Venusberg-Campus 1, 53127, Bonn, Germany. tatjana.tchumatchenko@uni-bonn.de.ORCID 0000-0001-9137-809X

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 945700
6 · The paper itself

Abstract

Neurons receive thousands of inputs onto their dendritic arbour, where individual synapses undergo activity-dependent plasticity. Long-lasting changes in postsynaptic strengths correlate with changes in spine head volume. The magnitude and direction of such structural plasticity - potentiation (sLTP) and depression (sLTD) - depend upon the number and spatial distribution of stimulated synapses. However, how neurons allocate resources to implement synaptic strength changes across space and time amongst neighbouring synapses remains unclear. Here we combined experimental and modelling approaches to explore the elementary processes underlying multi-spine plasticity. We used glutamate uncaging to induce sLTP at varying number of synapses sharing the same dendritic branch, and we built a model incorporating a dual role Ca

Indexed as

Dendritic SpinesNeuronal PlasticitySynapsesAnimalsCalciumDendritesGlutamic AcidHippocampusMaleModels, NeurologicalNeuronsRatsCalciumGlutamic Acid

Identifiers

PMID39217140
PMCPMC11365941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.