Evidence map›Paper›PMID 39216689›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2025

A scoping review of the legal and ethical challenges with the use of normothermic regional perfusion in controlled donation after circulatory determination of death from 2005 to 2023.

Briget da Graca, Matthew Snoddy, Conner Fischbach, Sudha Ramakrishnan, Macey L Levan, Brendan Parent, Giuliano Testa, Anji Wall

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Briget da GracaResearch Analytics and Development Cores, Baylor Scott & White Research Institute, Dallas, Texas, USA.
Matthew SnoddyDepartment of Abdominal Transplantation, Baylor University Medical Center, Dallas, Texas, USA; Baylor Scott and White Transplant Center for Innovation, Science, Policy Research and Ethics, Dallas, Texas, USA.
Conner FischbachDepartment of Abdominal Transplantation, Baylor University Medical Center, Dallas, Texas, USA.
Sudha RamakrishnanBaylor Health Sciences Library, Dallas, Texas, USA.
Macey L LevanDepartment of Surgery, New York University Grossman School of Medicine, New York, New York, USA.
Brendan ParentDivision of Medical Ethics, New York University Grossman School of Medicine, New York, New York, USA.
Giuliano TestaDepartment of Abdominal Transplantation, Baylor University Medical Center, Dallas, Texas, USA; Baylor Scott and White Transplant Center for Innovation, Science, Policy Research and Ethics, Dallas, Texas, USA.
Anji WallDepartment of Abdominal Transplantation, Baylor University Medical Center, Dallas, Texas, USA; Baylor Scott and White Transplant Center for Innovation, Science, Policy Research and Ethics, Dallas, Texas, USA. Electronic address: anji.wall@bswhealth.org.

Funding

Investigating Donor Authorization and Public Perceptions of Normothermic Regional Perfusion to Inform Ethical Organ Donation PracticesR01HL173157 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Brendan Parent · 2024 to 2026
$2.4M
NHLBI NIH HHS R01 HL173157
6 · The paper itself

Abstract

Use of normothermic regional perfusion (NRP) to enable organ reconditioning and assessment in donation after circulatory determination of death is controversial. We conducted a scoping review of peer-reviewed articles, news media, legal literature, and professional society position statements addressing ethical and/or legal issues in use of NRP in controlled donation after circulatory determination of death from January 1, 2005, to January 5, 2024. Thematic analysis, assessing the 4 principles of bioethics (autonomy, beneficence, nonmaleficence, and justice) and subthemes identified within each, was conducted for the 112 publications meeting inclusion criteria. More than 30 publications addressed the topic in each of 2022 and 2023, vs ≤6 per year previously. Nonmaleficence was the most frequently addressed bioethical principle (111/112 publications), and the most varied, with 14 subthemes. Attitudes toward NRP differed by type of NRP: of 72 publications discussing thoracoabdominal NRP, 22 (30.6%) were "In Favor," 39 (54.2%) were "Neutral," and 11 (15.3%) were "Against"; of 44 discussing abdominal NRP, 23 (52.3%) were "In Favor," 20 (45.5%) were "Neutral," and 1 (2.3%) was "Against." Attitudes differed by authors' country, degree, and affiliation, and by the clinical focus of the publishing journal. Overall, our review shows that the ethical and legal issues raised by NRP remain unresolved, and the debate centered on nonmaleficence.

Indexed as

Organ PreservationPerfusionTissue and Organ ProcurementDeathHumansOrgan TransplantationTissue Donorsdonation after circulatory determination of deathethicslawsnormothermic regional perfusion

Identifiers

PMID39216689
PMCPMC11700788

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.