ArticleCell reports. Medicine2024
Human milk microbiota, oligosaccharide profiles, and infant gut microbiome in preterm infants diagnosed with necrotizing enterocolitis.
Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Trends and hotspots in gut microbiota and neonatal necrotizing enterocolitis: a bibliometric analysis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Quality improvement interventions to prevent neonatal necrotizing enterocolitis: a systematic review.Frontiers in pediatrics · 2025Pooled it
- From homeostasis to dysregulation: human milk, microbial metabolites, and the preterm intestinal microenvironment in necrotizing enterocolitis.Translational pediatrics · 2026Review
- The human breast milk microbiome: a landscape review of its composition, origins, and impact on infant health.Archives of microbiology · 2026Review
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- Study of the gut microbiome profile in full-term infants with necrotizing enterocolits.World journal of clinical pediatrics · 2026Article
- The Human Milk Microbiome in Mothers of Very-Low-Birth-Weight Infants: A Systematic Review of Recent Clinical Studies.Children (Basel, Switzerland) · 2026Review
- Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases.Medical review (2021) · 2026Review
- Clostridia from preterm infants metabolize human milk oligosaccharides to suppress pathobionts and modulate intestinal function in organoids.Nature microbiology · 2026Article
- Tracing the early bacterial settlers in preterm and very-low birth-weight infants: first report of microbiota dynamics in South American neonates.Infection and immunity · 2026Article
- Gut microbiota profiling for risk stratification of surgical intervention in preterm infants with necrotizing enterocolitis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Risk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.Frontiers in pediatrics · 2026Review
- Review: microbial metabolites - a key to address gut inflammation and barrier dysfunction in the premature infant.Gut microbes · 2025Review
- Neonatal microbiome in the multiomics era: development and its impact on long-term health.Pediatric research · 2025Review
- Donor human milk pasteurization methods and the effect on milk components as they relate to Necrotizing enterocolitis.Seminars in fetal & neonatal medicine · 2025Review
- Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review.World journal of clinical pediatrics · 2025Article
- Integrated analysis of serum metabolomics and fecal microbiome in infants with necrotizing enterocolitis.Frontiers in microbiology · 2025Article
- Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review.Metabolites · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is a severe intestinal disease of very preterm infants with mother's own milk (MOM) providing protection, but the contribution of the MOM microbiota to NEC risk has not been explored. Here, we analyze MOM of 110 preterm infants (48 NEC, 62 control) in a cross-sectional study. Breast milk contains viable bacteria, but there is no significant difference in MOM microbiota between NEC and controls. Integrative analysis between MOM microbiota, human milk oligosaccharides (HMOs), and the infant gut microbiota shows positive correlations only between Acinetobacter in the infant gut and Acinetobacter and Staphylococcus in MOM. This study suggests that NEC protection from MOM is not modulated through the MOM microbiota. Thus, "'restoring" the MOM microbiota in donor human milk is unlikely to reduce NEC, and emphasis should instead focus on increasing fresh maternal human milk intake and researching different therapies for NEC prevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.