Evidence map›Paper›PMID 39216273›Full record

ReviewThrombosis research2024

Regulation of fibrinogen synthesis.

Dre'Von A Dobson, Richard J Fish, Paul S de Vries, Alanna C Morrison, Marguerite Neerman-Arbez, Alisa S Wolberg

Abstract readReview
In one paragraph

Review in Thrombosis research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dre'Von A DobsonDepartment of Pathology and Laboratory Medicine and UNC Blood Research Center, The University of North Carolina at Chapel Hill, NC, USA.
Richard J FishDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Marguerite Neerman-ArbezDepartment of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.
Alisa S WolbergDepartment of Pathology and Laboratory Medicine and UNC Blood Research Center, The University of North Carolina at Chapel Hill, NC, USA. Electronic address: alisa_wolberg@med.unc.edu.

Funding

Using genomics and functional biology to understand fibrinogen and its effect on thrombotic and atherosclerotic outcomesR01HL141291 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Alanna C Morrison, Alisa S. Wolberg · 2019 to 2026
$4.6M
Fibrinogen and Factor XIII in Venous ThrombosisR01HL126974 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alisa S. Wolberg · 2016 to 2026
$4.4M
NHLBI NIH HHS R01 HL126974NHLBI NIH HHS R01 HL141291
6 · The paper itself

Abstract

The plasma protein fibrinogen is encoded by 3 structural genes (FGA, FGB, and FGG) that are transcribed to mRNA, spliced, and translated to 3 polypeptide chains (Aα, Bβ, and γ, respectively). These chains are targeted for secretion, decorated with post-translational modifications, and assembled into a hexameric "dimer of trimers" (AαBβγ)

Indexed as

FibrinogenAnimalsHumansFibrinogenAcute phase responseCytokinesFibrinogenGene expressionmRNAPost-translational modification

Identifiers

PMID39216273
PMCPMC11381137

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.