Evidence map›Paper›PMID 39215942›Full record

ArticleDermatology and therapy2024

Vorasidenib-Induced Trichomegaly and Hypertrichosis: a New Side Effect in a Patient with Diffuse Astrocytoma.

Michela Starace, Stephano Cedirian, Luca Rapparini, Francesca Bruni, Bianca Maria Piraccini

Abstract read
In one paragraph

Article in Dermatology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michela StaraceDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 5, 40138, Bologna, BO, Italy.ORCID http://orcid.org/0000-0002-3981-1527
Stephano CedirianDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 5, 40138, Bologna, BO, Italy.ORCID http://orcid.org/0000-0002-9783-7864
Luca RappariniDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 5, 40138, Bologna, BO, Italy. luca.rapparini2@studio.unibo.it.ORCID http://orcid.org/0000-0002-4029-941X
Francesca BruniDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 5, 40138, Bologna, BO, Italy.ORCID http://orcid.org/0000-0001-7248-425X
Bianca Maria PiracciniDermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 5, 40138, Bologna, BO, Italy.ORCID http://orcid.org/0000-0001-6537-9689

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vorasidenib, an oral dual inhibitor targeting mutant enzymes isocitrate dehydrogenase 1 and 2, is utilized in the management of diffuse low-grade gliomas. Despite limited documentation of its adverse events, we present the case of a 44-year-old male who exhibited trichomegaly and hypertrichosis of body hair, eyebrows, and eyelashes following one month of vorasidenib treatment. Notably, the patient experienced diffuse hair regrowth on the scalp, including in areas affected by severe androgenetic alopecia. This report holds significance as it highlights a previously unreported side effect, thereby enhancing our understanding of emerging therapies for brain tumors and their associated adverse reactions.

Indexed as

AstrocytomaHypertrichosisOncology therapySide effectTrichomegalyVorasidenib

Identifiers

PMID39215942
PMCPMC11480275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.