Evidence map›Paper›PMID 39215853›Full record

ArticleInternational ophthalmology2024

The antibiotic resistance profiles of Pseudomonas aeruginosa in the Asia Cornea Society Infectious Keratitis Study.

Wei-Boon Khor, Rajamani Lakshminarayanan, Mercy Halleluyah Periayah, Venkatesh N Prajna, Prashant Garg, Namrata Sharma, Jodhbir S Mehta, Alvin Young, Panida Goseyarakwong, Vilavun Puangsricharern and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Antibiotic resistance mechanisms and global resistance patterns of Pseudomonas aeruginosa in microbial keratitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wei-Boon KhorSingapore National Eye Centre, Singapore, Singapore.
Rajamani LakshminarayananSingapore Eye Research Institute, Singapore, Singapore.
Mercy Halleluyah PeriayahSingapore Eye Research Institute, Singapore, Singapore.
Venkatesh N PrajnaAravind Eye Care System, Madurai, Tamil Nadu, India.
Prashant GargLV Prasad Eye Institute, Hyderabad, Telangana, India.
Namrata SharmaDr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Jodhbir S MehtaSingapore National Eye Centre, Singapore, Singapore.
Alvin YoungThe Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Panida GoseyarakwongDepartment of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Vilavun PuangsricharernDepartment of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ai Ling TanDepartment of Microbiology, Singapore General Hospital, Singapore, Singapore.
Roger W BeuermanSingapore Eye Research Institute, Singapore, Singapore.
Donald Tiang-Hwee TanSingapore National Eye Centre, Singapore, Singapore. dt@ers.clinic.
ACSIKS GROUP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the prevalence and antibiotic resistance profiles of Pseudomonas aeruginosa isolated from the Asia Cornea Society Infectious Keratitis Study (ACSIKS).

methodsAll bacterial isolates from ACSIKS underwent repeat microbiological identification in a central repository in Singapore. Minimum inhibitory concentration (MIC) determination was conducted for isolates of P. aeruginosa against thirteen antibiotics from 6 different classes, and categorized based on Clinical Laboratory Standard Institutes' reference ranges. The percentage rates of resistance (non-susceptibility) to each antibiotic included isolates of both intermediate and complete resistance. Multi-drug resistance (MDR) was defined as non-susceptibility to at least one agent in three or more antimicrobial classes.

resultsOf the 1493 unique bacterial specimens obtained from ACSIKS, 319 isolates were of P. aeruginosa. The majority of isolates were from centers in India (n = 118, 37%), Singapore (n = 90, 28.2%), Hong Kong (n = 31, 9.7%) and Thailand (n = 30, 9.4%). The cumulative antibiotic resistance rate was the greatest for polymyxin B (100%), ciprofloxacin (17.6%) and moxifloxacin (16.9%), and lowest for cefepime (11.6%) and amikacin (13.5%). Isolates from India demonstrated the highest antibiotic resistance rates of all the centers, and included moxifloxacin (47.5%) and ciprofloxacin (39.8%). Forty-eight of the 59 MDR isolates also originated from India. Antibiotic resistance rates were significantly lower in the other ACSIKS centers, and were typically less than 10%.

conclusionsThe antibiotic resistance profiles of P. aeruginosa varied between different countries. While it was low for most countries, substantial antibiotic resistance and a significant number of multi-drug resistant isolates were noted in the centers from India.

Indexed as

Anti-Bacterial AgentsEye Infections, BacterialMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsCorneal UlcerDrug Resistance, BacterialFemaleHumansKeratitisMalePrevalenceSocieties, MedicalAnti-Bacterial AgentsAnti-bacterial agentsAnti-infective agentsCorneaDrug resistance, multipleKeratitisPrevalencePseudomonas aeruginosa

Identifiers

PMID39215853
PMCPMC11365837

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