Evidence map›Paper›PMID 39215775›Full record

ArticleAnalytical and bioanalytical chemistry2024

The blistering warfare agent O-mustard (agent T) generates protein-adducts with human serum albumin useful for biomedical verification of exposure and forms intramolecular cross-links.

Marc-Michael Blum, Wolfgang Schmeißer, Marina Dentzel, Horst Thiermann, Harald John

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marc-Michael BlumBlum - Scientific Services, Björnsonweg 70d, 22587, Hamburg, Germany.ORCID http://orcid.org/0000-0003-1856-2071
Wolfgang SchmeißerBundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany.
Marina DentzelBundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany.
Horst ThiermannBundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany.ORCID http://orcid.org/0000-0001-6539-0263
Harald JohnBundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany. haraldjohn@bundeswehr.org.ORCID http://orcid.org/0000-0002-7126-6709

Funding

Deutsche Forschungsgemeinschaft GRK 2338
6 · The paper itself

Abstract

The highly blistering sulfur mustard analogue agent T (bis(2-chloroethylthioethyl) ether), also known as O-mustard or oxy-mustard, is a common impurity in military grade sulfur mustard (SM) and a component of mixtures such as "HT" that are still found in old munitions. Together with sesquimustard (Q), it is the most important SM analogue and tightly regulated as a Schedule 1 chemical under the Chemical Weapons Convention. We report the adducts of T with nucleophilic Cys

Indexed as

Chemical Warfare AgentsMustard GasSerum Albumin, HumanCross-Linking ReagentsHumansSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryChemical Warfare AgentsCross-Linking ReagentsMustard GasSerum Albumin, HumanCross-linksO-MustardProtein-adductSulfur mustardVerificationVesicant

Identifiers

PMID39215775
PMCPMC11493803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.