Evidence map›Paper›PMID 39215566›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.

Fan Yang, Hongwei Ma, Sanford L Boye, Shannon E Boye, Xi-Qin Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan YangDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0009-0008-1136-0411
Hongwei MaDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-3344-6549
Sanford L BoyePowell Gene Therapy Center, Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-8803-9369
Shannon E BoyeDivision of Cellular and Molecular Therapy, Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-7312-3197
Xi-Qin DingDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-0482-2226

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Engineering AAV for safe and efficient gene delivery to the human retinaR01EY024280 · NEI · UNIVERSITY OF FLORIDA · PI Shannon Elizabeth Boye · 2014 to 2026
$7.5M
Pilot Project ProgramP30GM122744 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LE, YUN ZHENG · 2017 to 2021
$5.5M
The Role of Endoplasmic Reticulum Calcium Channels in Cone Degeneration Resulting from CNG Channel DeficiencyR01EY027754 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DING, XI-QIN · 2017 to 2020
$1.5M
Thyroid Hormone Signaling and Cone Photoreceptor DegenerationR01EY033841 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DING, XI-QIN · 2022 to 2025
$1.5M
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY024280NEI NIH HHS R01 EY027754NEI NIH HHS R01 EY033841NIGMS NIH HHS P30 GM122744NIH HHS 5P30GM122744NIH HHS P30EY021725NIH HHS R01EY024280NIH HHS R01EY027754NIH HHS R01EY033841
6 · The paper itself

Abstract

Cone photoreceptor cyclic nucleotide-gated (CNG) channels play an essential role in phototransduction and cellular Ca

Indexed as

Cyclic Nucleotide-Gated Cation ChannelsEndoplasmic ReticulumEndoplasmic Reticulum StressRetinal Cone Photoreceptor CellsUbiquitin-Protein LigasesAnimalsEndoplasmic Reticulum-Associated DegradationMiceMice, Inbred C57BLMice, KnockoutCyclic Nucleotide-Gated Cation ChannelsSyvn1 protein, mouseUbiquitin-Protein LigasesCNG channelcone photoreceptorsERADER stressretinal degenerationSYVN1

Identifiers

PMID39215566
PMCPMC11419579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.