Evidence map›Paper›PMID 39215323›Full record

Trial reportBMC oral health2024

Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery.

Onur Koç, Nuray Er, Çiğdem Karaca, Kanİ Bilginaylar

3 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05466604 phase4completednot on this map

Comparison of the Effects of Hyaluronidase and Dexamethasone on Reduction of Postoperative Edema in Impacted Wisdom Teeth Surgery

TypeinterventionalSponsorHacettepe UniversityRan2019 to 2022Enrolled60ConditionsEdema, Pain, Trismus, Infection, Surgical SiteArmsHyaluronidase Injection mesomedica, Dexamethasone dekort
NCT07705165 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Split Body, Evaluator-blinded, Trial on the Effect of Tergase Injection (Berahyaluronidase Alfa) on Reducing Edema After Both Total Knee Arthroplasty

TypeinterventionalSponsorMan Soo KimRan2026 to 2028Enrolled30ConditionsOsteoarthritis, Knee, Postoperative Edema, Bilateral Total Knee ArthroplastyArmsBerahyaluronidase alfa
NCT07742826 narecruitingnot on this map

Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery

TypeinterventionalSponsorFinal International UniversityRan2024 to 2026Enrolled60ConditionsImpacted Mandibular Third Molar Extraction, Impacted Lower Third Molar, Impacted Wisdom ToothArmsPlatelet-rich fibrin (PRF), Dexamethasone, Amoxicillin/Clavulanic Acid, Paracetamol, Chlorhexidine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Onur KoçFaculty of Dentistry, Department of Oral and Maxillofacial Surgery, Hacettepe University, Sıhhiye, Ankara, Turkey. onurkoc101@gmail.com.
Nuray ErFaculty of Dentistry, Department of Oral and Maxillofacial Surgery, Hacettepe University, Sıhhiye, Ankara, Turkey.
Çiğdem KaracaFaculty of Dentistry, Department of Oral and Maxillofacial Surgery, Hacettepe University, Sıhhiye, Ankara, Turkey.
Kanİ BilginaylarFaculty of Dentistry, Department of Oral and Maxillofacial Surgery, Final International University, Nicosia, Cyprus.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimiting postoperative edema, pain, trismus, and infection is crucial for smooth healing. This prospective, controlled clinical trial investigated and compared the effectiveness of dexamethasone and hyaluronidase in relieving these complications.

methodsIn groups Ia and IIa, 8 mg of dexamethasone and 150 IU of hyaluronidase were administered following the removal of impacted teeth, respectively. The contralateral sides (groups Ib and IIb) were determined as control groups. Edema, pain, trismus, and infection were clinically evaluated on the 1st, 2nd, 3rd, and 7th postoperative days.

results60 patients were enrolled in the study. Hyaluronidase provided significantly more edema relief than dexamethasone on the 1st, 2nd, 3rd, and 7th postoperative days (P = 0.031, 0.002, 0.000, and 0.009, respectively). No statistical difference was found between dexamethasone and hyaluronidase in VAS and rescue analgesic intake amount values for all time points. Hyaluronidase was more effective in reducing trismus than dexamethasone on the 2nd and 3rd postoperative days (P = 0.029, 0.024, respectively). Neither of the agents significantly increased the postoperative infection rate.

conclusionsHyaluronidase can be selected when postoperative excessive edema and trismus are anticipated. Dexamethasone may be a cost-effective option if postoperative pain control is merely targeted.

trial registrationThis trial was registered in the Clinical Trials Protocol Registration and Results System (ClinicalTrials.gov identifier number: NCT05466604) on 20/07/2022.

Indexed as

DexamethasoneEdemaHyaluronoglucosaminidaseMolar, ThirdPostoperative PainTooth, ImpactedTrismusAdolescentAdultAnti-Inflammatory AgentsFemaleHumansMalePain MeasurementPostoperative ComplicationsProspective StudiesAnti-Inflammatory AgentsDexamethasoneHyaluronoglucosaminidaseDiscomfort reductionEnzyme therapyPost-surgery maintenanceRestricted jaw movementSteroidal treatmentSurgical healing

Identifiers

PMID39215323
PMCPMC11365265

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.