Evidence map›Paper›PMID 39215253›Full record

Observational studyBMC oral health2024

Interleukin-6, -17, and -35 levels in association with clinical status in stage III and stage IV periodontitis: a cross-sectional study.

Müge Altaca, Elif Ilke Cebesoy, Necla Asli Kocak-Oztug, Ilknur Bingül, Emine Cifcibasi

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05306860 (Investigation of the Relationships and Clinical Parameters Between IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Individuals With Grade B-C Stage III-IV Periodontitis), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05306860 completednot on this map

Investigation of the Relationships and Clinical Parameters Between IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Individuals With Grade B-C Stage III-IV Periodontitis

Typeobservational_patient_registrySponsorIstanbul UniversityRan2022 to 2023Enrolled60ConditionsPeriodontitisArmsNo intervention was applied to the groups the samples will be collected in terms of the diagnosis (periodontitis, healthy)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. The Role of IL-17 in Periodontitis and Its Systemic Connections.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Müge AltacaFaculty of Dentistry, Department of Periodontology, Istanbul University, Istanbul, 34116, Turkey.ORCID http://orcid.org/0009-0006-5850-9565
Elif Ilke CebesoyFaculty of Dentistry, Department of Periodontology, Istanbul University, Istanbul, 34116, Turkey.ORCID http://orcid.org/0009-0007-0979-1661
Necla Asli Kocak-OztugFaculty of Dentistry, Department of Periodontology, Istanbul University, Istanbul, 34116, Turkey.ORCID http://orcid.org/0000-0003-2513-6345
Ilknur BingülFaculty of Medicine, Department of Medical Biochemistry, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-6432-3541
Emine CifcibasiFaculty of Dentistry, Department of Periodontology, Istanbul University, Istanbul, 34116, Turkey. emineyek@istanbul.edu.tr.ORCID http://orcid.org/0000-0002-5361-0940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study compared the concentrations of interleukin (IL)-6, IL-17, and IL-35 in the gingival crevicular fluid of periodontally healthy participants with individuals who had stage III and IV periodontitis.

methodsIn total, 60 participants with stage III grade B-C (n = 12)-stage IV grade C (n = 18) periodontitis and 30 healthy controls were included in this cross-sectional study. Full-mouth clinical periodontal measurements were performed. Concentrations of IL-6, IL-17, and IL-35 were determined using enzyme-linked immunosorbent assays. Parametric/nonparametric methods, Pearson's/Spearman's correlation, and logistic regression methods were used for data analyses.

resultsThe periodontitis group exhibited significantly higher levels of IL-6, IL-17, and IL-35 compared with the healthy group (p < 0.001). IL-17 levels had a positive correlation with pocket depth (PD) (r = 0.395; p = 0.031) in the periodontitis group. IL-6, IL-17, and IL-35 levels were associated with periodontitis (odds ratio [OR] = 1.344, 95% confidence interval [CI] = 1.159-1.56; OR = 1.063, 95% CI = 1.025-1.102; OR = 1.261, 95% CI = 1.110-1.434, respectively) (p < 0.001, p = 0.001, p < 0.001, respectively). Full-mouth and sampling sites PD and clinical attachment loss (CAL) values were significantly higher in the periodontitis group than in the healthy group (p < 0.001).

conclusionsThis study revealed upregulated levels of IL-6, IL-17, and IL-35 in periodontitis patients compared to healthy individuals. IL-17 shows a correlation with increased PD. These findings suggest a potential association between these cytokines and severe and advanced periodontitis.

trial registrationThe trial was registered in ClinicalTrials.gov with this identifier NCT05306860 on 24/01/2022.

Indexed as

Gingival Crevicular FluidInterleukin-17Interleukin-6InterleukinsPeriodontitisAdultAgedCase-Control StudiesCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPeriodontal IndexProspective StudiesIL6 protein, humanInterleukin-17interleukin-35, humanInterleukin-6InterleukinsGingival crevicular fluidInflammationInterleukin-17Interleukin-35Interleukin-6Periodontitis

Identifiers

PMID39215253
PMCPMC11363592

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.