ArticleBMC pregnancy and childbirth2024
Predictive value of inflammatory markers (NLR, PLR, MLR, SII, SIRI, PIV, IG, and MII) for latency period in Preterm premature rupture of membranes (PPROM) pregnancies.
Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Evaluation of predictive factors for morbidity and mortality in patients undergoing surgery for peptic ulcer perforation.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Evaluation of the Hemoglobin, Albumin, Lymphocyte, and Platelet Score and Inflammatory Markers in Preterm Premature Rupture of Membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Association between the systemic immune-inflammation index within 1 h after birth and the risk of neonatal respiratory distress syndrome in preterm infants.BMC pediatrics · 2026Article
- Association of inflammatory biomarkers during pregnancy and the postpartum period with the risk of postpartum anxiety symptoms.Brain, behavior, & immunity - health · 2026Article
- Evaluation of the SII and HALP scores in predicting perinatal outcomes in pregnancies with preterm premature rupture of membranes.BMC pregnancy and childbirth · 2026Article
- Hematologic Ratios as Early Biomarkers for Preterm Premature Rupture of Membranes: A Prospective Cohort Study.Cureus · 2026Article
- Pan-immune-inflammation value as a predictor of loss of ambulation in duchenne muscular dystrophy: a retrospective cohort study.BMC pediatrics · 2026Article
- Can perioperative shifts in inflammatory indices predict maternal and neonatal outcomes following cervical cerclage?BMC pregnancy and childbirth · 2026Article
- A novel integrated inflammation response score (IIRS) for predicting all-cause and cardiovascular mortality among cancer survivors.American journal of cancer research · 2026Article
- Predictive Value of Neutrophils, Lymphocytes, Platelets, Neutrophil-Lymphocyte Ratio (NLR), and Platelets-Lymphocyte Ratio (PLR) in Preterm Labor: Single and Combined Indices.Obstetrics and gynecology international · 2026Article
- Association between complete blood count-derived hematological inflammatory ratios and nutritional risk in elderly patients with acute ischemic stroke.Frontiers in neurology · 2026Observational
- Predictive utility of systemic inflammatory response index and pan-immune-inflammatory value in assessing myocardial infarction risk among cases with unstable angina.Scientific reports · 2025Article
- Machine learning-based prediction of preeclampsia using first-trimester inflammatory markers and red blood cell indices.BMC pregnancy and childbirth · 2025Article
- The Role of Systemic Inflammatory Indices in Predicting Composite Adverse Outcomes of Peripartum Hemorrhage Treated with Fibrinogen Concentrate.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Association of Early Pregnancy Inflammatory Indices with Preterm Birth and Perinatal Outcomes in Pregnancies with Pregestational Diabetes.Journal of clinical medicine · 2025Article
- Effects of preoperative inflammation parameters on regional anesthesia blockade times in pregnant women.Pakistan journal of medical sciences · 2025Article
- Maternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.Frontiers in medicine · 2025Article
- Association Between Systemic Immune-Inflammation Index in Early Pregnancy and Preeclampsia: A Multicenter Cohort Study.Journal of inflammation research · 2025Article
- Interpretable machine learning model for identification and risk factor of premature rupture of membranes (PROM) and its association with nutritional inflammatory index: a retrospective study.Frontiers in medicine · 2025Article
- The association of the pan-immune-inflammation value with mortality in patients monitored in the intensive care unit after cardiopulmonary resuscitation.Frontiers in medicine · 2025Article
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10 authors.
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Abstract
backgroundOur study aimed to investigate the value of inflammatory indices in predicting the latency period until birth in patients with preterm premature rupture of membranes (PPROM).
methodsThis retrospective study was conducted on PPROM cases between 24 and 34 weeks of gestation at Ankara Etlik City Hospital Perinatology Department from October 2023 to April 2024. A total of 146 participants were divided into two groups: Group 1 included 73 patients who gave birth within 72 hours (h) of PPROM diagnosis, and Group 2 included 73 patients who gave birth after 72 h.
resultsThis study evaluated the prognostic significance of various inflammatory markers neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune inflammation index (SII), systemic inflammatory response index (SIRI), pan-immune inflammation value (PIV), immature granulocytes (IG), multi-inflammatory index (MII)-1, MII-2, and MII-3 in predicting the latency period in patients with PPROM. Only MII-1, MII-2, and MII-3 reliably predicted labor within 72 h. The cut-off value for MII-1 was > 48.3, with a sensitivity of 57.7% and specificity of 57.3% (AUC: 0.598, 95% CI: 0.503-0.692, p = 0.042). For MII-2, the cut-off was > 1037.6, with a sensitivity of 57.7% and specificity of 57.3% (AUC: 0.611, 95% CI: 0.516-0.705, p = 0.021). MII-3 had a cut-off of > 10919.9, with a sensitivity of 53.5% and specificity of 52% (AUC: 0.595, 95% CI: 0.501-0.690, p = 0.046).
conclusionOur findings show that, among NLR, PLR, MLR, SII, SIRI, PIV, IG, MII-1, MII-2, and MII-3, only MII-1, MII-2, and MII-3 levels are statistically significant in predicting birth timing.
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