Evidence map›Paper›PMID 39215196›Full record

ArticlePediatric research2025

Changes in skin barrier over the first four days of life: a cross-sectional study.

Weitao Tang, Yuanzhou Peng, Yalan Dou, Yi Zhang, Xiaohua Zhang, Liuhui Wang, Ming Li, Weili Yan, Ying Ye

Registry-linked trialAbstract read
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In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02889081 (Maternal Key Nutritional Factors and Offspring's Atopic Dermatitis), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02889081 completednot on this map

Maternal Key Nutritional Factors and Offspring's Atopic Dermatitis

Typeobservational_patient_registrySponsorChildren's Hospital of Fudan UniversityRan2016 to 2018Enrolled487ConditionsAtopic DermatitisArmsmaternal biological folate level, maternal biological Vitamin D level
3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Weitao TangDepartment of Dermatology, Children's Hospital of Fudan University &National Children Medical Center, Shanghai, China.
Yuanzhou PengDepartment of Clinical Epidemiology, Children's Hospital of Fudan University & National Children Medical Center, Shanghai, China.
Yalan DouDepartment of Clinical Epidemiology, Children's Hospital of Fudan University & National Children Medical Center, Shanghai, China.
Yi ZhangDepartment of Clinical Epidemiology, Children's Hospital of Fudan University & National Children Medical Center, Shanghai, China.
Xiaohua ZhangDepartment of Obstetrics, Shanghai Minhang Maternal and Children Health Care Hospital, Shanghai, China.
Liuhui WangDepartment of Dermatology, Children's Hospital of Fudan University &National Children Medical Center, Shanghai, China.
Ming LiDepartment of Dermatology, Children's Hospital of Fudan University &National Children Medical Center, Shanghai, China.
Weili YanDepartment of Clinical Epidemiology, Children's Hospital of Fudan University & National Children Medical Center, Shanghai, China.
Ying YeDepartment of Dermatology, Children's Hospital of Fudan University &National Children Medical Center, Shanghai, China. ying_ye@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to evaluate the trajectory of skin barrier properties in full-term newborns during the first four days after birth.

methodsBased on the MKNFOAD cohort (NCT02889081), transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin pH, and sebum content at five anatomical sites (cheek, forehead, volar forearm, abdomen, and dorsal lower leg) were examined once within 96 h after birth in 384 full-term infants. Multivariable linear regression analysis was performed to assess variations in these skin barrier parameters with age adjusted for gestational age, neonate's sex, parents' allergy history, delivery mode, amniotic fluid characteristics, and birth weight. The regression coefficient (ß) and 95% confidence interval were reported.

resultsWe analyzed a total of 384 neonates including 198 (51.6%) boys. TEWL values remained stable and showed no significant association with age (days). pH values exhibited a declining trend with age (p for trend <0.001). Both SCH values and sebum content grew with age (p for trend <0.001).

conclusionDuring the first four days after birth, the skin TEWL remained stable, pH decreased, and the SCH and sebum content increased over time. These findings provide insights into the neonatal skin physiological development at the beginning of life. IMPACT: From birth to 96 h, TEWL was stable, pH showed a steep decline, SCH and sebum content increased. This study provides the first evidence of skin adaptation in the newborn due to changes in utero to after birth in the first 4 days of life in an Asian population. These findings will provide a new theoretical basis for neonatal skin physiology and clinical strategies for guiding newborn skin care.

Indexed as

SkinSkin Physiological PhenomenaBirth WeightCross-Sectional StudiesFemaleGestational AgeHumansHydrogen-Ion ConcentrationInfant, NewbornMaleSebumWater Loss, Insensible

Identifiers

PMID39215196

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