Evidence map›Paper›PMID 39215195›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2025

Feasibility and safety of surfactant administration via laryngeal mask airway as first-line therapy for a select newborn population: results of a standardized clinical protocol.

Zuzanna Kubicka, Eyad Zahr, Henry A Feldman, Tamara Rousseau, Theresa Welgs, Amy Ditzel, Diana Perry, Molly Lacy, Carolyn O'Rourke, Bonnie Arzuaga

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zuzanna KubickaDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA. zkubicka5@gmail.com.ORCID 0000-0003-1396-6050
Eyad ZahrDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Henry A FeldmanHarvard Medical School, Boston, MA, USA.
Tamara RousseauDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Theresa WelgsDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Amy DitzelDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Diana PerryDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Molly LacyDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Carolyn O'RourkeDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.
Bonnie ArzuagaDepartment of Pediatrics, South Shore Hospital, Weymouth, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives(1) To demonstrate feasibility and safety of surfactant administration via laryngeal mask airway (LMA) as a first-line therapy. (2) To measure treatment success, defined as avoidance of intubation/invasive mechanical ventilation, and determine if specific clinical variables could predict success/failure. STUDY

designObservational cohort with eligible infants given surfactant using one type of LMA via standardized protocol. Data was captured prospectively followed by retrospective chart review.

results120 infants ≥1250 g and 28.3-41.1 weeks gestation were included. First-line LMA surfactant therapy was successful in 70% of the infants and those infants weaned to room air significantly quicker than infants requiring subsequent intubation/mechanical ventilation (p = 0.002 by 72 h, p = 0.001 by 96 h). Clinical variables assessed could not predict treatment success/failure. Complications were infrequent and did not differ between groups.

conclusionFirst-line LMA surfactant is feasible and safe for certain infants. Prediction of treatment success was not possible in our cohort.

Indexed as

Feasibility StudiesLaryngeal MasksPulmonary SurfactantsRespiratory Distress Syndrome, NewbornClinical ProtocolsFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleRespiration, ArtificialRetrospective StudiesTreatment OutcomePulmonary Surfactants

Identifiers

PMID39215195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.