Evidence map›Paper›PMID 39215057›Full record

ReviewNature reviews. Immunology2024

Redefining our vision: an updated guide to the ocular immune system.

Mengliang Wu, Erica L Fletcher, Holly R Chinnery, Laura E Downie, Scott N Mueller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. iScience · 2026
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  6. Article
  7. Review
  8. Article
  9. Review
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  11. Article
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  14. Review
  15. Acute Inflammation Drives Corneal Pathological Regeneration.Investigative ophthalmology & visual science · 2026
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengliang WuDepartment of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia.ORCID http://orcid.org/0000-0002-0142-6623
Erica L FletcherDepartment of Anatomy and Physiology, The University of Melbourne, Carlton, Victoria, Australia.
Holly R Chinnery *Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia. holly.chinnery@lei.org.au.ORCID http://orcid.org/0000-0003-4238-4324
Laura E Downie *Department of Optometry and Vision Sciences, The University of Melbourne, Carlton, Victoria, Australia. ldownie@unimelb.edu.au.ORCID http://orcid.org/0000-0002-1596-2259
Scott N Mueller *Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. smue@unimelb.edu.au.ORCID http://orcid.org/0000-0002-3838-3989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune system has long been considered distinct, owing to the so-called 'immune privilege' of its component tissues. More recently, intravital imaging and transcriptomic techniques have reshaped scientific understanding of the ocular immune landscape, such as revealing the specialization of immune cell populations in the various tissues of the eye. As knowledge of the phenotypes of corneal and retinal immune cells has evolved, links to both the systemic immune system, and the central and peripheral nervous systems, have been identified. Using intravital imaging, T cells have recently been found to reside in, and actively patrol, the healthy human cornea. Disease-associated retinal microglia with links to retinal degeneration have also been identified. This Review provides an updated guide to the ocular immune system, highlighting current knowledge of the immune cells that are present in steady-state and specific diseased ocular tissues, as well as evidence for their relationship to systemic disease. In addition, we discuss emerging intravital imaging techniques that can be used to visualize immune cell morphology and dynamics in living human eyes and how these could be applied to advance understanding of the human immune system.

Indexed as

EyeImmune SystemAnimalsCorneaEye DiseasesHumansImmune PrivilegeRetinaT-LymphocytesVision, Ocular

Identifiers

PMID39215057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.