Evidence map›Paper›PMID 39215050›Full record

ArticleScientific reports2024

Biocompatibility and bone regeneration with elastin-like recombinamer-based catalyst-free click gels.

I N Camal Ruggieri, M Aimone, D Juanes-Gusano, A Ibáñez-Fonseca, O Santiago, M Stur, J P Mardegan Issa, L R Missana, M Alonso, J C Rodríguez-Cabello and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

I N Camal RuggieriLABOATEM. Osteoarticular Biology, Tissue Engineering and Emerging Therapies Laboratory, School of Medicine, National Rosario University, Rosario, Argentina. ivannadircamalruggieri@gmail.com.
M AimoneLABOATEM. Osteoarticular Biology, Tissue Engineering and Emerging Therapies Laboratory, School of Medicine, National Rosario University, Rosario, Argentina.
D Juanes-GusanoBIOFORGE Lab, University of Valladolid, CIBER-BBN, Valladolid, Spain.
A Ibáñez-FonsecaBIOFORGE Lab, University of Valladolid, CIBER-BBN, Valladolid, Spain.
O SantiagoLABOATEM. Osteoarticular Biology, Tissue Engineering and Emerging Therapies Laboratory, School of Medicine, National Rosario University, Rosario, Argentina.
M SturLABOATEM. Osteoarticular Biology, Tissue Engineering and Emerging Therapies Laboratory, School of Medicine, National Rosario University, Rosario, Argentina.
J P Mardegan IssaRibeirão Preto School of Dentistry, São Paulo University, São Paulo, Brazil.
L R MissanaExperimental Pathology and Tissue Engineering Laboratory, School of Dentistry, National Tucumán University, Tucumán, Argentina.
M AlonsoBIOFORGE Lab, University of Valladolid, CIBER-BBN, Valladolid, Spain. malonso@eii.uva.es.
J C Rodríguez-CabelloBIOFORGE Lab, University of Valladolid, CIBER-BBN, Valladolid, Spain.
S FeldmanLABOATEM. Osteoarticular Biology, Tissue Engineering and Emerging Therapies Laboratory, School of Medicine, National Rosario University, Rosario, Argentina. saryfeldman@gmail.com.

Funding

Junta de Castilla y León 0624_2IQBIONEURO_6_ESpanish Government MAT2016-78903-RSpanish Government PID2019-110709RB-100Spanish Government PID2021-122444OB-I00Spanish Government RED2018-102417-T
6 · The paper itself

Abstract

Large bone defects are a significant health problem today with various origins, including extensive trauma, tumours, or congenital musculoskeletal disorders. Tissue engineering, and in particular bone tissue engineering, aims to respond to this demand. As such, we propose a specific model based on Elastin-Like Recombinamers-based click-chemistry hydrogels given their high biocompatibility and their potent on bone regeneration effect conferred by different bioactive sequences. In this work we demonstrate, using biochemistry, histology, histomorphometry and imaging techniques, the biocompatibility of our matrix and its potent effect on bone regeneration in a model of bone parietal lesion in female New Zealand rabbits.

Indexed as

Biocompatible MaterialsBone RegenerationElastinHydrogelsTissue EngineeringAnimalsClick ChemistryFemaleRabbitsTissue ScaffoldsBiocompatible MaterialsElastinHydrogelsBoneElastinScaffoldTissue engineering

Identifiers

PMID39215050
PMCPMC11364658

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.